A turn-on fluorescent sensor for detecting nickel in living cells

Sheel C. Dodani; Qiwen He; Christopher J. Chang

doi:10.1021/ja906500m

A turn-on fluorescent sensor for detecting nickel in living cells

Sheel C. Dodani, Qiwen He, Christopher J. Chang

Research output: Contribution to journal › Article › peer-review

218 Scopus citations

Abstract

(Figure Presented) We present the synthesis and properties of Nickelsensor-1 (NS1), a new water-soluble, turn-on fluorescent sensor that is capable of selectively responding to Ni²⁺ in aqueous solution and in living cells. NS1 combines a BODIPY chromophore and a mixed N/O/S receptor to provide good selectivity for Ni²⁺ over a range of biologically abundant metal ions in aqueous solution. In addition to these characteristics, confocal microscopy experiments further show that NS1 can be delivered into living cells and report changes in intracellular Ni²⁺ levels in a respiratory cell model.

Original language	English (US)
Pages (from-to)	18020-18021
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	131
Issue number	50
DOIs	https://doi.org/10.1021/ja906500m
State	Published - Dec 23 2009
Externally published	Yes

All Science Journal Classification (ASJC) codes

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja906500m

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abstract = "(Figure Presented) We present the synthesis and properties of Nickelsensor-1 (NS1), a new water-soluble, turn-on fluorescent sensor that is capable of selectively responding to Ni2+ in aqueous solution and in living cells. NS1 combines a BODIPY chromophore and a mixed N/O/S receptor to provide good selectivity for Ni2+ over a range of biologically abundant metal ions in aqueous solution. In addition to these characteristics, confocal microscopy experiments further show that NS1 can be delivered into living cells and report changes in intracellular Ni2+ levels in a respiratory cell model.",

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AU - He, Qiwen

AU - Chang, Christopher J.

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N2 - (Figure Presented) We present the synthesis and properties of Nickelsensor-1 (NS1), a new water-soluble, turn-on fluorescent sensor that is capable of selectively responding to Ni2+ in aqueous solution and in living cells. NS1 combines a BODIPY chromophore and a mixed N/O/S receptor to provide good selectivity for Ni2+ over a range of biologically abundant metal ions in aqueous solution. In addition to these characteristics, confocal microscopy experiments further show that NS1 can be delivered into living cells and report changes in intracellular Ni2+ levels in a respiratory cell model.

AB - (Figure Presented) We present the synthesis and properties of Nickelsensor-1 (NS1), a new water-soluble, turn-on fluorescent sensor that is capable of selectively responding to Ni2+ in aqueous solution and in living cells. NS1 combines a BODIPY chromophore and a mixed N/O/S receptor to provide good selectivity for Ni2+ over a range of biologically abundant metal ions in aqueous solution. In addition to these characteristics, confocal microscopy experiments further show that NS1 can be delivered into living cells and report changes in intracellular Ni2+ levels in a respiratory cell model.

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A turn-on fluorescent sensor for detecting nickel in living cells

Abstract

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