A synthesis of (-)-indolactam V

M. F. Semmelhack, Hakjune Rhee

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(-)-Indolactam V (1) was synthesized in 14 steps from 2,6-dinitrotoluene in 15% overall yield via enantiospecific SN2 displacement of a chiral triflate with the 4-amino group of a 4-aminoindole and coupling of 3-bromomethyl indole with Schöllkopf's asymmetric bislactim ether.

Original languageEnglish (US)
Pages (from-to)1395-1398
Number of pages4
JournalTetrahedron Letters
Issue number9
StatePublished - Feb 26 1993

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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