A Synthesis of Ibogamine

Martin E. Kuehne; Paul J. Reider

doi:10.1021/jo00209a020

A Synthesis of Ibogamine

Martin E. Kuehne, Paul J. Reider

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

A synthesis of ibogamine was developed by elaboration of 5-carbomethoxy-3-ethylcyclohexene. The latter was obtained as a 1:1 epimeric mixture from condensation of diethyl (2-ethyl-3-oxopropyl)malonate with triphenylvinylphosphonium bromide, followed by hydrolysis, decarboxylation, and esterification.

Original language	English (US)
Pages (from-to)	1464-1467
Number of pages	4
Journal	Journal of Organic Chemistry
Volume	50
Issue number	9
DOIs	https://doi.org/10.1021/jo00209a020
State	Published - May 1985
Externally published	Yes

All Science Journal Classification (ASJC) codes

Organic Chemistry

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title = "A Synthesis of Ibogamine",

abstract = "A synthesis of ibogamine was developed by elaboration of 5-carbomethoxy-3-ethylcyclohexene. The latter was obtained as a 1:1 epimeric mixture from condensation of diethyl (2-ethyl-3-oxopropyl)malonate with triphenylvinylphosphonium bromide, followed by hydrolysis, decarboxylation, and esterification.",

author = "Kuehne, {Martin E.} and Reider, {Paul J.}",

year = "1985",

month = may,

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language = "English (US)",

volume = "50",

pages = "1464--1467",

journal = "Journal of Organic Chemistry",

issn = "0022-3263",

publisher = "American Chemical Society",

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T1 - A Synthesis of Ibogamine

AU - Kuehne, Martin E.

AU - Reider, Paul J.

PY - 1985/5

Y1 - 1985/5

N2 - A synthesis of ibogamine was developed by elaboration of 5-carbomethoxy-3-ethylcyclohexene. The latter was obtained as a 1:1 epimeric mixture from condensation of diethyl (2-ethyl-3-oxopropyl)malonate with triphenylvinylphosphonium bromide, followed by hydrolysis, decarboxylation, and esterification.

AB - A synthesis of ibogamine was developed by elaboration of 5-carbomethoxy-3-ethylcyclohexene. The latter was obtained as a 1:1 epimeric mixture from condensation of diethyl (2-ethyl-3-oxopropyl)malonate with triphenylvinylphosphonium bromide, followed by hydrolysis, decarboxylation, and esterification.

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U2 - 10.1021/jo00209a020

DO - 10.1021/jo00209a020

M3 - Article

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SP - 1464

EP - 1467

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

IS - 9

ER -

A Synthesis of Ibogamine

Abstract

All Science Journal Classification (ASJC) codes

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