A subset of viral transcripts packaged within human cytomegalovirus particles

Wade A. Bresnahan, Thomas Shenk

Research output: Contribution to journalArticle

142 Scopus citations

Abstract

A human cytomegalovirus gene array was used to identify a previously unidentified class of viral transcripts. These transcripts, termed virion RNAs, were packaged within infectious virions and were delivered to the host cell on infection. This mechanism of herpesvirus gene expression allows for viral genes to be expressed within an infected cell immediately after virus entry and in the absence of transcription from the viral genome.

Original languageEnglish (US)
Pages (from-to)2373-2376
Number of pages4
JournalScience
Volume288
Issue number5475
DOIs
StatePublished - Jun 30 2000

All Science Journal Classification (ASJC) codes

  • General

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