@article{ac57810a4fb541a38dcced883cf6970d,
title = "A Stereocontrolled Annulation of the Taccalonolide Epoxy Lactone onto the Molecular Framework of trans-Androsterone",
abstract = "A robust and scalable route to the taccalonolide skeleton starting from trans-androsterone is presented. The synthesis features a cyclic hydroboration carbonylation reaction, which effectively establishes the trans-hydrindane DE ring junction in a remarkable annulation reaction, as well as a Claisen rearrangement and a catalytic Ullmann-type cyclization. This work is part of a larger effort to uncover new clinical candidates from the taccalonolide class of anticancer agents through advances in chemical synthesis.",
author = "Jakob Danielsson and Sun, {Diana X.} and Chen, {Xiao Yang} and Risinger, {April L.} and Mooberry, {Susan L.} and Sorensen, {Erik J.}",
note = "Funding Information: We gratefully acknowledge The Swedish Chemical Society and The Swedish Pharmaceutical Society for postdoctoral fellowships to J.D. and the National Institute of General Medical Sciences grant GM065483 for financial support. We thank Drs. Susan L. Mooberry and April L. Risinger of the School of Medicine, University of Texas, San Antonio for the bioactivity assays on compounds 17 and 18. We also thank Dr. Istva{\'n} Pelczer of Princeton University for assisting our structural and stereochemical characterizations by the methods of NMR spectroscopy. Publisher Copyright: {\textcopyright} 2017 American Chemical Society.",
year = "2017",
month = sep,
day = "15",
doi = "10.1021/acs.orglett.7b02349",
language = "English (US)",
volume = "19",
pages = "4892--4895",
journal = "Organic letters",
issn = "1523-7060",
publisher = "American Chemical Society",
number = "18",
}