A soluble base for the copper-catalyzed imidazole N-arylations with aryl halides

Longbin Liu, Mike Frohn, Ning Xi, Celia Dominguez, Randy Hungate, Paul J. Reider

Research output: Contribution to journalArticle

169 Scopus citations

Abstract

CuI-catalyzed N-arylation of imidazoles with aryl bromides has been achieved in a near-homogeneous system that utilizes tetraethylammonium carbonate as base, 8-hydroxyquinoline as ligand, and H2O as cosolvent. Preliminary results with aryl chlorides are also reported.

Original languageEnglish (US)
Pages (from-to)10135-10138
Number of pages4
JournalJournal of Organic Chemistry
Volume70
Issue number24
DOIs
StatePublished - Nov 25 2005
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

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