A smart magnetic resonance contrast agent for selective copper sensing

Emily L. Que; Christopher J. Chang

doi:10.1021/ja065264l

A smart magnetic resonance contrast agent for selective copper sensing

Emily L. Que, Christopher J. Chang

Research output: Contribution to journal › Article › peer-review

150 Scopus citations

Abstract

We describe the synthesis and properties of Copper-Gad-1 (CG1), a new type of smart magnetic resonance (MR) sensor for selective detection of copper. CG1 is composed of a gadolinium contrast agent core tethered to copper-selective recognition motif. Cu²⁺-induced modulation of inner-sphere water access to the Gd³⁺ center provides a sensing mechanism for reporting Cu²⁺ levels by reading out changes in longitudinal proton relaxivity values. CG1 features good selectivity for Cu²⁺ overabundant biological cations and a 41% increase in relaxivity upon Cu²⁺ binding and is capable of detecting micromolar changes in Cu²⁺ concentrations in aqueous media.

Original language	English (US)
Pages (from-to)	15942-15943
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	128
Issue number	50
DOIs	https://doi.org/10.1021/ja065264l
State	Published - Dec 20 2006
Externally published	Yes

All Science Journal Classification (ASJC) codes

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja065264l

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abstract = "We describe the synthesis and properties of Copper-Gad-1 (CG1), a new type of smart magnetic resonance (MR) sensor for selective detection of copper. CG1 is composed of a gadolinium contrast agent core tethered to copper-selective recognition motif. Cu2+-induced modulation of inner-sphere water access to the Gd3+ center provides a sensing mechanism for reporting Cu2+ levels by reading out changes in longitudinal proton relaxivity values. CG1 features good selectivity for Cu2+ overabundant biological cations and a 41% increase in relaxivity upon Cu2+ binding and is capable of detecting micromolar changes in Cu2+ concentrations in aqueous media.",

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AB - We describe the synthesis and properties of Copper-Gad-1 (CG1), a new type of smart magnetic resonance (MR) sensor for selective detection of copper. CG1 is composed of a gadolinium contrast agent core tethered to copper-selective recognition motif. Cu2+-induced modulation of inner-sphere water access to the Gd3+ center provides a sensing mechanism for reporting Cu2+ levels by reading out changes in longitudinal proton relaxivity values. CG1 features good selectivity for Cu2+ overabundant biological cations and a 41% increase in relaxivity upon Cu2+ binding and is capable of detecting micromolar changes in Cu2+ concentrations in aqueous media.

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A smart magnetic resonance contrast agent for selective copper sensing

Abstract

All Science Journal Classification (ASJC) codes

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