A simple synthesis and evaluation of the bicyclo[8.3.0] enediyne framework

M. F. Semmelhack, Mark Jaskowski, Richmond Sarpong, Douglas M. Ho

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

A synthesis of a simple trans fused [8.3.0]bicyclic enediyne framework was developed from cyclopentanone-trans-3,4-dicarboxylate. The rates of rearrangement of several derivatives of the framework were measured, and correlated with structural features. Preliminary studies to adjust the configuration about the ring fusion, expected to be an activation step, are discussed.

Original languageEnglish (US)
Pages (from-to)4947-4950
Number of pages4
JournalTetrahedron Letters
Volume43
Issue number28
DOIs
StatePublished - Jul 8 2002

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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