A signal sequence is not sufficient to lead β-galactosidase out of the cytoplasm

Felipe Moreno, Audree V. Fowler, Michael Hall, Thomas J. Silhavy, Irving Zabin, Maxime Schwartz

Research output: Contribution to journalArticlepeer-review

89 Scopus citations

Abstract

Escherichia coli strains have been constructed in which lacZ, the gene for the cytoplasmic enzyme β-galactosidase, is fused to lamB, the gene for an outer membrane protein. One such strain produces a β-galactosidase which remains cytoplasmic even though it possesses the complete signal sequence of the lamB protein precursor at the amino-terminal end.

Original languageEnglish (US)
Pages (from-to)356-359
Number of pages4
JournalNature
Volume286
Issue number5771
DOIs
StatePublished - Dec 1 1980
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General

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