A putative cell signal encoded by the folded gastrulation gene coordinates cell shape changes during Drosophila gastrulation

Michael Costa, Ellen T. Wilson, Eric Wieschaus

Research output: Contribution to journalArticle

212 Scopus citations

Abstract

The folded gastrulation (fog) gene is required during Drosophila gastrulation for two morphogenetic movements, formation of the ventral furrow and invagination of the posterior midgut primordium. fog coordinates cell shape changes during these invaginations by inducing apical constriction of cells in spatially and temporally defined manners. fog is expressed in the invagination primordia in a pattern that precisely precedes the pattern of constrictions. Overexpression of fog in the dorsoanterior region of the embryo induces ectopic constrictions, indicating localization of fog transcripts may define domains of cell shape changes. fog encodes a novel protein with a putative signal sequence but no potential transmembrane domains. We suggest fog functions as a secreted signal that activates the G protein α subunit encoded by concertina in neighboring cells. Our analyses indicate that cell-cell communication ensures the rapid, orderly progression of constriction initiations from the middle of invagination primordia out toward the margins.

Original languageEnglish (US)
Pages (from-to)1075-1089
Number of pages15
JournalCell
Volume76
Issue number6
DOIs
StatePublished - Mar 25 1994

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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