Abstract
A common model for the time σL (sec) taken by a DNA strand of length L (cm) to unravel is to assume that new points of unraveling occur along the strand as a Poisson process of rate λ 1/(cm x sec) in space-time and that the unraveling propagates at speed v/2 (cm/sec) in each direction until time σL. We solve the open problem to determine the distribution of σL by finding its Laplace transform and using it to show that as x = L2λ/v → ∞, σL is nearly a constant:σL= 1 λvlog L2λ v 1 2We also derive (modulo some small gaps) the more precise limiting asymptotic formula: for - ∞ < θ < ∞,PσL< 1 λvψ 1 2[log(L2 λ v)]+ θ ψ 1 2[log(L2 λ v)]→e-e-θwhere ψ is defined by the equation: ψ(x) = log ψ(x)+x, x≥1. These results are obtained by interchanging the role of space and time to uncover an underlying Markov process which can be studied in detail.
Original language | English (US) |
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Pages (from-to) | 1177 |
Number of pages | 1 |
Journal | Mathematical and Computer Modelling |
Volume | 12 |
Issue number | 9 |
DOIs | |
State | Published - 1989 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Modeling and Simulation
- Computer Science Applications