A number of synthetic strategies to the Cox-2 specific inhibitor 1 have been described. These studies have led to the identification of a novel pyridine construction using annulation of ketone 2 using a vinamidinium species 29 and ammonia in 97% assay yield. Three approaches to the synthesis of ketone 2 are described that allow for its preparation in large quantities in >65% overall yield from methyl 6-methylnicotinate.
|Original language||English (US)|
|Number of pages||6|
|Journal||Journal of Organic Chemistry|
|State||Published - Dec 15 2000|
All Science Journal Classification (ASJC) codes
- Organic Chemistry