A practical synthesis of 5‐(chloromethyl)furo[2,3‐b]pyridine, a key intermediate for the HIV protease inhibitor, L‐754,394

M. Bhupathy, David A. Conlon, Kenneth M. Wells, John R. Nelson, Paul J. Reider, Kai Rossen, Jess W. Sager, R. P. Volante, Bruce D. Dorsey, Jacob M. Hoffman, Sally A. Joseph, Stacey L. Mcdaniel

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

A practical synthesis of 5‐(chloromethyl)furo[2,3‐b]pyridine (10), the side chain used to incorporate a key pharmacophore of the HIV protease inhibitor, L‐754,394, is described. The synthesis was accomplished in ten steps and in 15% overall yield from commercially available methyl 2‐furoate.

Original languageEnglish (US)
Pages (from-to)1283-1287
Number of pages5
JournalJournal of Heterocyclic Chemistry
Volume32
Issue number4
DOIs
StatePublished - Jan 1 1995
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

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