Abstract
A practical synthesis of 5‐(chloromethyl)furo[2,3‐b]pyridine (10), the side chain used to incorporate a key pharmacophore of the HIV protease inhibitor, L‐754,394, is described. The synthesis was accomplished in ten steps and in 15% overall yield from commercially available methyl 2‐furoate.
Original language | English (US) |
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Pages (from-to) | 1283-1287 |
Number of pages | 5 |
Journal | Journal of Heterocyclic Chemistry |
Volume | 32 |
Issue number | 4 |
DOIs | |
State | Published - 1995 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Organic Chemistry