A practical synthesis for the core structure of a family of selective prostaglandin D2 receptor antagonists

Kevin R. Campos, Michel Journet, Dongwei Cai, Jason J. Kowal, Sandra Lee, Robert D. Larsen, Paul J. Reider

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

A convergent synthesis was developed for the production of the core structure of prostaglandin D2 receptor antagonists for the treatment of allergic rhinitis. The key steps in this synthesis were a highly diastereoselective alkylation of (+)-nopinone, a chemo- and stereoselective reduction of an oxime to an amine, and a well-controlled reduction of an aminoalkyne to a (Z)-olefin.

Original languageEnglish (US)
Pages (from-to)2338-2342
Number of pages5
JournalJournal of Organic Chemistry
Volume68
Issue number6
DOIs
StatePublished - Mar 21 2003
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

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