A convergent synthesis was developed for the production of the core structure of prostaglandin D2 receptor antagonists for the treatment of allergic rhinitis. The key steps in this synthesis were a highly diastereoselective alkylation of (+)-nopinone, a chemo- and stereoselective reduction of an oxime to an amine, and a well-controlled reduction of an aminoalkyne to a (Z)-olefin.
|Original language||English (US)|
|Number of pages||5|
|Journal||Journal of Organic Chemistry|
|State||Published - Mar 21 2003|
All Science Journal Classification (ASJC) codes
- Organic Chemistry