A practical preparation of diisopropyl phosphoryl protected amino acids

K. M.J. Brands, K. Wiedbrauk, J. M. Williams, U. H. Dolling, P. J. Reider

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

N-Diisopropyl phosphoryl protected amino acids can be prepared in high yield and without racemization by slow addition of sodium hypochlorite to a solution of the amino acid and diisopropylphosphite in water while carefully maintaining a constant pH via the addition of sodium hydroxide.

Original languageEnglish (US)
Pages (from-to)9583-9586
Number of pages4
JournalTetrahedron Letters
Volume39
Issue number52
DOIs
StatePublished - Dec 24 1998
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Keywords

  • Amino acids and derivatives
  • Phosphoramidates
  • ProteCting groups

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