A practical preparation of diisopropyl phosphoryl protected amino acids

K. M.J. Brands; K. Wiedbrauk; J. M. Williams; U. H. Dolling; P. J. Reider

doi:10.1016/S0040-4039(98)02300-4

A practical preparation of diisopropyl phosphoryl protected amino acids

K. M.J. Brands, K. Wiedbrauk, J. M. Williams, U. H. Dolling, P. J. Reider

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

N-Diisopropyl phosphoryl protected amino acids can be prepared in high yield and without racemization by slow addition of sodium hypochlorite to a solution of the amino acid and diisopropylphosphite in water while carefully maintaining a constant pH via the addition of sodium hydroxide.

Original language	English (US)
Pages (from-to)	9583-9586
Number of pages	4
Journal	Tetrahedron Letters
Volume	39
Issue number	52
DOIs	https://doi.org/10.1016/S0040-4039(98)02300-4
State	Published - Dec 24 1998
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

Keywords

Amino acids and derivatives
Phosphoramidates
ProteCting groups

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10.1016/S0040-4039(98)02300-4

Cite this

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title = "A practical preparation of diisopropyl phosphoryl protected amino acids",

abstract = "N-Diisopropyl phosphoryl protected amino acids can be prepared in high yield and without racemization by slow addition of sodium hypochlorite to a solution of the amino acid and diisopropylphosphite in water while carefully maintaining a constant pH via the addition of sodium hydroxide.",

keywords = "Amino acids and derivatives, Phosphoramidates, ProteCting groups",

author = "Brands, {K. M.J.} and K. Wiedbrauk and Williams, {J. M.} and Dolling, {U. H.} and Reider, {P. J.}",

year = "1998",

month = dec,

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doi = "10.1016/S0040-4039(98)02300-4",

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pages = "9583--9586",

journal = "Tetrahedron Letters",

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T1 - A practical preparation of diisopropyl phosphoryl protected amino acids

AU - Brands, K. M.J.

AU - Wiedbrauk, K.

AU - Williams, J. M.

AU - Dolling, U. H.

AU - Reider, P. J.

PY - 1998/12/24

Y1 - 1998/12/24

N2 - N-Diisopropyl phosphoryl protected amino acids can be prepared in high yield and without racemization by slow addition of sodium hypochlorite to a solution of the amino acid and diisopropylphosphite in water while carefully maintaining a constant pH via the addition of sodium hydroxide.

AB - N-Diisopropyl phosphoryl protected amino acids can be prepared in high yield and without racemization by slow addition of sodium hypochlorite to a solution of the amino acid and diisopropylphosphite in water while carefully maintaining a constant pH via the addition of sodium hydroxide.

KW - Amino acids and derivatives

KW - Phosphoramidates

KW - ProteCting groups

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U2 - 10.1016/S0040-4039(98)02300-4

DO - 10.1016/S0040-4039(98)02300-4

M3 - Article

AN - SCOPUS:0032564548

SN - 0040-4039

VL - 39

SP - 9583

EP - 9586

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 52

ER -

A practical preparation of diisopropyl phosphoryl protected amino acids

Abstract

All Science Journal Classification (ASJC) codes

Keywords

Access to Document

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