N-Diisopropyl phosphoryl protected amino acids can be prepared in high yield and without racemization by slow addition of sodium hypochlorite to a solution of the amino acid and diisopropylphosphite in water while carefully maintaining a constant pH via the addition of sodium hydroxide.
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry
- Amino acids and derivatives
- ProteCting groups