A Packaged Multiplexed Fluorescent Biomolecular Sensor Array and Ultralow-Power Wireless Interface in CMOS for Ingestible Electronic Applications

Chengjie Zhu, Lingyu Hong, Haw Yang, Kaushik Sengupta

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Ingestible electronics capable of laboratory quality biomolecular analysis occupying pill-sized volume, operating at sub-mW with a robust wireless interface can transform medical diagnostics and personalized healthcare. Miniaturization of complex biomolecular systems in such a volume is extremely challenging, including a wireless interface that is capable of robust communication through inches of tissue. This article presents for the first time a fully packaged biosensor system with transmitter (Tx)/receiver (Rx) antennas coupled to a single CMOS chip that integrates a low-power wireless interface and a 15-pixel fluorescence biosensor array with on-chip nanoplasmonic optical filters. The IC, operating across multiple industrial, scientific, and medical (ISM)/medical implant communication system (MICS) bands, employs pulse-pause-encoded ASK/OOK modulation, and achieves reception energy efficiency of 28 pJ/bit at 7 Mb/s and-58 dBm of sensitivity with 196 μ W of dc power. The entire biocompatible package is miniaturized to a size of 1.2 × 2.5 cm2. To the best of the authors' knowledge, this work demonstrates for the first time a packaged bio-pill with in situ biomolecular sensing and quantification with pM sensitivity in CMOS ICs that also encompasses wireless transmission capability through inches of tissue at state-of-the-art energy efficiency.

Original languageEnglish (US)
Pages (from-to)24060-24074
Number of pages15
JournalIEEE Sensors Journal
Volume22
Issue number24
DOIs
StatePublished - Dec 15 2022

All Science Journal Classification (ASJC) codes

  • Instrumentation
  • Electrical and Electronic Engineering

Keywords

  • Biomolecular
  • CMOS
  • biomolecular sensor
  • ingestible
  • pill
  • wireless telemetry

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