TY - GEN
T1 - A Packaged Ingestible Bio-Pill with 15-Pixel Multiplexed Fluorescence Nucleic-Acid Sensor and Bi-Directional Wireless Interface for In-Vivo Bio-Molecular Sensing
AU - Zhu, Chengjie
AU - Wen, Yuhan
AU - Liu, Tao
AU - Yang, Haw
AU - Sengupta, Kaushik
N1 - Publisher Copyright:
© 2020 IEEE.
PY - 2020/6
Y1 - 2020/6
N2 - This paper presents the first wireless multiplexed fluorescence-based bio-molecular sensing system in a pill form for GI-track health monitoring application. This application is geared towards quasi-real time analysis of microbiome distribution through nucleic acid detection. A silicon chip integrates both the sensor and the wireless system, including a 124 μW ULP wireless receiver with -59 dBm sensitivity, a dual mode FSK/OOK transmitter, and a fluorescent sensor array with 1.6 attomoles and 100 pM of target DNA detection limit per pixel. The complete package includes a CMOS fluorescent sensor chip with integrated filter, a prototyped UV LED and optical waveguide, functionalized bioslip, off-chip power management and Tx/Rx antenna that fits in a standard FDA approved capsule size 000.
AB - This paper presents the first wireless multiplexed fluorescence-based bio-molecular sensing system in a pill form for GI-track health monitoring application. This application is geared towards quasi-real time analysis of microbiome distribution through nucleic acid detection. A silicon chip integrates both the sensor and the wireless system, including a 124 μW ULP wireless receiver with -59 dBm sensitivity, a dual mode FSK/OOK transmitter, and a fluorescent sensor array with 1.6 attomoles and 100 pM of target DNA detection limit per pixel. The complete package includes a CMOS fluorescent sensor chip with integrated filter, a prototyped UV LED and optical waveguide, functionalized bioslip, off-chip power management and Tx/Rx antenna that fits in a standard FDA approved capsule size 000.
UR - http://www.scopus.com/inward/record.url?scp=85090249011&partnerID=8YFLogxK
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U2 - 10.1109/VLSICircuits18222.2020.9163060
DO - 10.1109/VLSICircuits18222.2020.9163060
M3 - Conference contribution
AN - SCOPUS:85090249011
T3 - IEEE Symposium on VLSI Circuits, Digest of Technical Papers
BT - 2020 IEEE Symposium on VLSI Circuits, VLSI Circuits 2020 - Proceedings
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 2020 IEEE Symposium on VLSI Circuits, VLSI Circuits 2020
Y2 - 16 June 2020 through 19 June 2020
ER -