A Packaged Ingestible Bio-Pill with 15-Pixel Multiplexed Fluorescence Nucleic-Acid Sensor and Bi-Directional Wireless Interface for In-Vivo Bio-Molecular Sensing

Chengjie Zhu, Yuhan Wen, Tao Liu, Haw Yang, Kaushik Sengupta

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This paper presents the first wireless multiplexed fluorescence-based bio-molecular sensing system in a pill form for GI-track health monitoring application. This application is geared towards quasi-real time analysis of microbiome distribution through nucleic acid detection. A silicon chip integrates both the sensor and the wireless system, including a 124 μW ULP wireless receiver with -59 dBm sensitivity, a dual mode FSK/OOK transmitter, and a fluorescent sensor array with 1.6 attomoles and 100 pM of target DNA detection limit per pixel. The complete package includes a CMOS fluorescent sensor chip with integrated filter, a prototyped UV LED and optical waveguide, functionalized bioslip, off-chip power management and Tx/Rx antenna that fits in a standard FDA approved capsule size 000.

Original languageEnglish (US)
Title of host publication2020 IEEE Symposium on VLSI Circuits, VLSI Circuits 2020 - Proceedings
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781728199429
DOIs
StatePublished - Jun 2020
Event2020 IEEE Symposium on VLSI Circuits, VLSI Circuits 2020 - Honolulu, United States
Duration: Jun 16 2020Jun 19 2020

Publication series

NameIEEE Symposium on VLSI Circuits, Digest of Technical Papers
Volume2020-June

Conference

Conference2020 IEEE Symposium on VLSI Circuits, VLSI Circuits 2020
CountryUnited States
CityHonolulu
Period6/16/206/19/20

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Electrical and Electronic Engineering

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  • Cite this

    Zhu, C., Wen, Y., Liu, T., Yang, H., & Sengupta, K. (2020). A Packaged Ingestible Bio-Pill with 15-Pixel Multiplexed Fluorescence Nucleic-Acid Sensor and Bi-Directional Wireless Interface for In-Vivo Bio-Molecular Sensing. In 2020 IEEE Symposium on VLSI Circuits, VLSI Circuits 2020 - Proceedings [9163060] (IEEE Symposium on VLSI Circuits, Digest of Technical Papers; Vol. 2020-June). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/VLSICircuits18222.2020.9163060