A one-two punch of miR-126/126* against metastasis

Guangwen Ren; Yibin Kang

doi:10.1038/ncb2703

A one-two punch of miR-126/126* against metastasis

Guangwen Ren, Yibin Kang

Research output: Contribution to journal › Short survey › peer-review

21 Scopus citations

Abstract

MicroRNAs regulate cancer metastasis by modulating both the intrinsic properties of tumour cells and their interactions with the tumour stroma. Both strands of the miR-126/miR-126* duplex are now shown to simultaneously target the Sdf-1α cytokine to reduce the recruitment of mesenchymal stem cells and inflammatory monocytes to primary tumours, thereby inhibiting lung metastasis.

Original language	English (US)
Pages (from-to)	231-233
Number of pages	3
Journal	Nature cell biology
Volume	15
Issue number	3
DOIs	https://doi.org/10.1038/ncb2703
State	Published - Mar 2013

All Science Journal Classification (ASJC) codes

Cell Biology

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10.1038/ncb2703

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title = "A one-two punch of miR-126/126* against metastasis",

abstract = "MicroRNAs regulate cancer metastasis by modulating both the intrinsic properties of tumour cells and their interactions with the tumour stroma. Both strands of the miR-126/miR-126* duplex are now shown to simultaneously target the Sdf-1α cytokine to reduce the recruitment of mesenchymal stem cells and inflammatory monocytes to primary tumours, thereby inhibiting lung metastasis.",

author = "Guangwen Ren and Yibin Kang",

year = "2013",

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doi = "10.1038/ncb2703",

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AU - Ren, Guangwen

AU - Kang, Yibin

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AB - MicroRNAs regulate cancer metastasis by modulating both the intrinsic properties of tumour cells and their interactions with the tumour stroma. Both strands of the miR-126/miR-126* duplex are now shown to simultaneously target the Sdf-1α cytokine to reduce the recruitment of mesenchymal stem cells and inflammatory monocytes to primary tumours, thereby inhibiting lung metastasis.

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M3 - Short survey

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JO - Nature cell biology

JF - Nature cell biology

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A one-two punch of miR-126/126* against metastasis

Abstract

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