A one-two punch of miR-126/126* against metastasis

Guangwen Ren, Yibin Kang

Research output: Contribution to journalShort surveypeer-review

17 Scopus citations

Abstract

MicroRNAs regulate cancer metastasis by modulating both the intrinsic properties of tumour cells and their interactions with the tumour stroma. Both strands of the miR-126/miR-126* duplex are now shown to simultaneously target the Sdf-1α cytokine to reduce the recruitment of mesenchymal stem cells and inflammatory monocytes to primary tumours, thereby inhibiting lung metastasis.

Original languageEnglish (US)
Pages (from-to)231-233
Number of pages3
JournalNature Cell Biology
Volume15
Issue number3
DOIs
StatePublished - Mar 1 2013

All Science Journal Classification (ASJC) codes

  • Cell Biology

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