A one-two punch of miR-126/126* against metastasis

Guangwen Ren, Yibin Kang

Research output: Contribution to journalShort survey

17 Scopus citations

Abstract

MicroRNAs regulate cancer metastasis by modulating both the intrinsic properties of tumour cells and their interactions with the tumour stroma. Both strands of the miR-126/miR-126* duplex are now shown to simultaneously target the Sdf-1α cytokine to reduce the recruitment of mesenchymal stem cells and inflammatory monocytes to primary tumours, thereby inhibiting lung metastasis.

Original languageEnglish (US)
Pages (from-to)231-233
Number of pages3
JournalNature Cell Biology
Volume15
Issue number3
DOIs
StatePublished - Mar 1 2013

All Science Journal Classification (ASJC) codes

  • Cell Biology

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