Abstract
Substantial structural transformations of much use in complex chemical synthesis can be achieved by channeling the reactivity of highly unsaturated molecules. This report describes the direct conversion of an acyclic polyunsaturated diketone to the HIV-1 Rev/Rev-responsive element inhibitor harziphilone under mild reaction conditions.
Original language | English (US) |
---|---|
Pages (from-to) | 12064-12066 |
Number of pages | 3 |
Journal | Proceedings of the National Academy of Sciences of the United States of America |
Volume | 101 |
Issue number | 33 |
DOIs | |
State | Published - Aug 17 2004 |
All Science Journal Classification (ASJC) codes
- General
Keywords
- Baylis-Hillman reaction
- Conjugate additions
- Domino reactions
- Electrocyclizations
- Nucleophilic catalysis