A nuclear escort for β-catenin

Nicholas S. Tolwinski; Eric Wieschaus

doi:10.1038/ncb0704-579

A nuclear escort for β-catenin

Nicholas S. Tolwinski
, Eric Wieschaus

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Understanding the regulation of β-catenin, a key component of the Wnt signalling pathway, has important implications for developmental processes, maintenance of stem cells and the formation of many cancers. The latest report suggests that a nuclear complex consisting of Pygopus and Legless is required for β-catenin's nuclear localization, thereby promoting its transcriptional activity.

Original language	English (US)
Pages (from-to)	579-580
Number of pages	2
Journal	Nature cell biology
Volume	6
Issue number	7
DOIs	https://doi.org/10.1038/ncb0704-579
State	Published - Jul 2004

All Science Journal Classification (ASJC) codes

Cell Biology

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10.1038/ncb0704-579

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abstract = "Understanding the regulation of β-catenin, a key component of the Wnt signalling pathway, has important implications for developmental processes, maintenance of stem cells and the formation of many cancers. The latest report suggests that a nuclear complex consisting of Pygopus and Legless is required for β-catenin's nuclear localization, thereby promoting its transcriptional activity.",

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AB - Understanding the regulation of β-catenin, a key component of the Wnt signalling pathway, has important implications for developmental processes, maintenance of stem cells and the formation of many cancers. The latest report suggests that a nuclear complex consisting of Pygopus and Legless is required for β-catenin's nuclear localization, thereby promoting its transcriptional activity.

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JO - Nature cell biology

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A nuclear escort for β-catenin

Abstract

All Science Journal Classification (ASJC) codes

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