@article{f2c9b1477d594ebeaf2df0ec41fd5f09,
title = "A new heart for a new head in vertebrate cardiopharyngeal evolution",
abstract = "It has been more than 30 years since the publication of the new head hypothesis, which proposed that the vertebrate head is an evolutionary novelty resulting from the emergence of neural crest and cranial placodes. Neural crest generates the skull and associated connective tissues, whereas placodes produce sensory organs. However, neither crest nor placodes produce head muscles, which are a crucial component of the complex vertebrate head. We discuss emerging evidence for a surprising link between the evolution of head muscles and chambered hearts-both systems arise from a common pool of mesoderm progenitor cells within the cardiopharyngeal field of vertebrate embryos. We consider the origin of this field in non-vertebrate chordates and its evolution in vertebrates.",
author = "Rui Diogo and Kelly, {Robert G.} and Lionel Christiaen and Michael Levine and Ziermann, {Janine M.} and Molnar, {Julia L.} and Noden, {Drew M.} and Eldad Tzahor",
note = "Funding Information: Acknowledgements We thank T. Miyashita and F. Razy-Krajka for their detailed reviews of the manuscript. We are thankful to the Dean of Howard University (HU) College of Medicine, M. Johnson, and the Chair of HU Department of Anatomy, D. Orlic, for helping to organize, financially and logistically, the First Evo-Devo Meeting On Heart and Head Muscles at HU (May, 2014) that led to the publication of this Review. We also thank the other participants at the workshop: A. Kahana, P. Okkema, A. Vincent, T. Hirasawa, S. Tajbakhsh, S. Dietrich and R. Knight. L.C. is supported by National Institutes of Health (NIH)/National Institute of General Medical Sciences (NIGMS) grant R01GM096032 and NIH/National Heart, Lung and Blood Instiute (NHLBI) grant R01HL108643, E.T. by the European Research Council and Israel Science Foundation, R.D. and J.Z. by HU College of Medicine, R.G.K. by Inserm, the Agence Nationale pour la Recherche, Association Fran{\c c}aise contre les Myopathies and Fondation pour la Recherche M{\'e}dicale, and M.L. by NIH grant NS076542. Publisher Copyright: {\textcopyright} 2015 Macmillan Publishers Limited. All rights reserved.",
year = "2015",
month = apr,
day = "23",
doi = "10.1038/nature14435",
language = "English (US)",
volume = "520",
pages = "466--473",
journal = "Nature",
issn = "0028-0836",
publisher = "Nature Publishing Group",
number = "7548",
}