A new framework for the cycloaromatization of enediynes under mild conditions

M. F. Semmelhack; Yansong Gu; Douglas M. Ho

doi:10.1016/S0040-4039(97)01263-X

A new framework for the cycloaromatization of enediynes under mild conditions

M. F. Semmelhack, Yansong Gu, Douglas M. Ho

Chemistry

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

An enediyne unit in a bicyclo[8.3.0] framework with a trans ring fusion has been designed, synthesized, and evaluated as a new functional model for the enediyne toxins. The cycloaromatization reaction proceeds with a half-life time of 13-14 hr at 25°C.

Original language	English (US)
Pages (from-to)	5583-5586
Number of pages	4
Journal	Tetrahedron Letters
Volume	38
Issue number	32
DOIs	https://doi.org/10.1016/S0040-4039(97)01263-X
State	Published - Aug 1997

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(97)01263-X

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title = "A new framework for the cycloaromatization of enediynes under mild conditions",

abstract = "An enediyne unit in a bicyclo[8.3.0] framework with a trans ring fusion has been designed, synthesized, and evaluated as a new functional model for the enediyne toxins. The cycloaromatization reaction proceeds with a half-life time of 13-14 hr at 25°C.",

author = "Semmelhack, \{M. F.\} and Yansong Gu and Ho, \{Douglas M.\}",

year = "1997",

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T1 - A new framework for the cycloaromatization of enediynes under mild conditions

AU - Semmelhack, M. F.

AU - Gu, Yansong

AU - Ho, Douglas M.

PY - 1997/8

Y1 - 1997/8

N2 - An enediyne unit in a bicyclo[8.3.0] framework with a trans ring fusion has been designed, synthesized, and evaluated as a new functional model for the enediyne toxins. The cycloaromatization reaction proceeds with a half-life time of 13-14 hr at 25°C.

AB - An enediyne unit in a bicyclo[8.3.0] framework with a trans ring fusion has been designed, synthesized, and evaluated as a new functional model for the enediyne toxins. The cycloaromatization reaction proceeds with a half-life time of 13-14 hr at 25°C.

UR - https://www.scopus.com/pages/publications/0030761988

UR - https://www.scopus.com/inward/citedby.url?scp=0030761988&partnerID=8YFLogxK

U2 - 10.1016/S0040-4039(97)01263-X

DO - 10.1016/S0040-4039(97)01263-X

M3 - Article

AN - SCOPUS:0030761988

SN - 0040-4039

VL - 38

SP - 5583

EP - 5586

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 32

ER -

A new framework for the cycloaromatization of enediynes under mild conditions

Abstract

All Science Journal Classification (ASJC) codes

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