A new framework for the cycloaromatization of enediynes under mild conditions

M. F. Semmelhack, Yansong Gu, Douglas M. Ho

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

An enediyne unit in a bicyclo[8.3.0] framework with a trans ring fusion has been designed, synthesized, and evaluated as a new functional model for the enediyne toxins. The cycloaromatization reaction proceeds with a half-life time of 13-14 hr at 25°C.

Original languageEnglish (US)
Pages (from-to)5583-5586
Number of pages4
JournalTetrahedron Letters
Volume38
Issue number32
DOIs
StatePublished - Aug 1 1997

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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