A Neural Circuit Mechanism for Encoding Aversive Stimuli in the Mesolimbic Dopamine System

Johannes W. de Jong; Seyedeh Atiyeh Afjei; Iskra Pollak Dorocic; James R. Peck; Christine Liu; Christina K. Kim; Lin Tian; Karl Deisseroth; Stephan Lammel

doi:10.1016/j.neuron.2018.11.005

A Neural Circuit Mechanism for Encoding Aversive Stimuli in the Mesolimbic Dopamine System

Johannes W. de Jong, Seyedeh Atiyeh Afjei, Iskra Pollak Dorocic, James R. Peck, Christine Liu, Christina K. Kim, Lin Tian, Karl Deisseroth, Stephan Lammel

Research output: Contribution to journal › Article › peer-review

366 Scopus citations

Abstract

The mesolimbic dopamine system plays an important role in reward, reinforcement learning and motivated behaviors. de Jong et al. reveal a circuit mechanism that implicates a subtype of mesolimbic dopamine neurons in the encoding of aversive-predicting stimuli.

Original language	English (US)
Pages (from-to)	133-151.e7
Journal	Neuron
Volume	101
Issue number	1
DOIs	https://doi.org/10.1016/j.neuron.2018.11.005
State	Published - Jan 2 2019
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Neuroscience

Keywords

aversion
dopamine
dorsal raphe
lateral hypothalamus
nucleus accumbens
reward
ventral tegmental area

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10.1016/j.neuron.2018.11.005

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title = "A Neural Circuit Mechanism for Encoding Aversive Stimuli in the Mesolimbic Dopamine System",

abstract = "The mesolimbic dopamine system plays an important role in reward, reinforcement learning and motivated behaviors. de Jong et al. reveal a circuit mechanism that implicates a subtype of mesolimbic dopamine neurons in the encoding of aversive-predicting stimuli.",

keywords = "aversion, dopamine, dorsal raphe, lateral hypothalamus, nucleus accumbens, reward, ventral tegmental area",

author = "\{de Jong\}, \{Johannes W.\} and Afjei, \{Seyedeh Atiyeh\} and \{Pollak Dorocic\}, Iskra and Peck, \{James R.\} and Christine Liu and Kim, \{Christina K.\} and Lin Tian and Karl Deisseroth and Stephan Lammel",

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doi = "10.1016/j.neuron.2018.11.005",

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AU - de Jong, Johannes W.

AU - Afjei, Seyedeh Atiyeh

AU - Pollak Dorocic, Iskra

AU - Peck, James R.

AU - Liu, Christine

AU - Kim, Christina K.

AU - Tian, Lin

AU - Deisseroth, Karl

AU - Lammel, Stephan

PY - 2019/1/2

Y1 - 2019/1/2

N2 - The mesolimbic dopamine system plays an important role in reward, reinforcement learning and motivated behaviors. de Jong et al. reveal a circuit mechanism that implicates a subtype of mesolimbic dopamine neurons in the encoding of aversive-predicting stimuli.

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KW - aversion

KW - dopamine

KW - dorsal raphe

KW - lateral hypothalamus

KW - nucleus accumbens

KW - reward

KW - ventral tegmental area

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A Neural Circuit Mechanism for Encoding Aversive Stimuli in the Mesolimbic Dopamine System

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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