A Neural Circuit Mechanism for Encoding Aversive Stimuli in the Mesolimbic Dopamine System

Johannes W. de Jong; Seyedeh Atiyeh Afjei; Iskra Pollak Dorocic; James R. Peck; Christine Liu; Christina K. Kim; Lin Tian; Karl Deisseroth; Stephan Lammel

doi:10.1016/j.neuron.2018.11.005

A Neural Circuit Mechanism for Encoding Aversive Stimuli in the Mesolimbic Dopamine System

Johannes W. de Jong
, Seyedeh Atiyeh Afjei
, Iskra Pollak Dorocic
, James R. Peck
, Christine Liu
, Christina K. Kim
, Lin Tian
, Karl Deisseroth
, Stephan Lammel

Research output: Contribution to journal › Article › peer-review

378 Scopus citations

Abstract

The mesolimbic dopamine system plays an important role in reward, reinforcement learning and motivated behaviors. de Jong et al. reveal a circuit mechanism that implicates a subtype of mesolimbic dopamine neurons in the encoding of aversive-predicting stimuli.

Original language	English (US)
Pages (from-to)	133-151.e7
Journal	Neuron
Volume	101
Issue number	1
DOIs	https://doi.org/10.1016/j.neuron.2018.11.005
State	Published - Jan 2 2019
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Neuroscience

Keywords

aversion
dopamine
dorsal raphe
lateral hypothalamus
nucleus accumbens
reward
ventral tegmental area

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10.1016/j.neuron.2018.11.005

Cite this

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title = "A Neural Circuit Mechanism for Encoding Aversive Stimuli in the Mesolimbic Dopamine System",

abstract = "The mesolimbic dopamine system plays an important role in reward, reinforcement learning and motivated behaviors. de Jong et al. reveal a circuit mechanism that implicates a subtype of mesolimbic dopamine neurons in the encoding of aversive-predicting stimuli.",

keywords = "aversion, dopamine, dorsal raphe, lateral hypothalamus, nucleus accumbens, reward, ventral tegmental area",

author = "\{de Jong\}, \{Johannes W.\} and Afjei, \{Seyedeh Atiyeh\} and \{Pollak Dorocic\}, Iskra and Peck, \{James R.\} and Christine Liu and Kim, \{Christina K.\} and Lin Tian and Karl Deisseroth and Stephan Lammel",

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AU - de Jong, Johannes W.

AU - Afjei, Seyedeh Atiyeh

AU - Pollak Dorocic, Iskra

AU - Peck, James R.

AU - Liu, Christine

AU - Kim, Christina K.

AU - Tian, Lin

AU - Deisseroth, Karl

AU - Lammel, Stephan

PY - 2019/1/2

Y1 - 2019/1/2

N2 - The mesolimbic dopamine system plays an important role in reward, reinforcement learning and motivated behaviors. de Jong et al. reveal a circuit mechanism that implicates a subtype of mesolimbic dopamine neurons in the encoding of aversive-predicting stimuli.

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KW - dopamine

KW - dorsal raphe

KW - lateral hypothalamus

KW - nucleus accumbens

KW - reward

KW - ventral tegmental area

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A Neural Circuit Mechanism for Encoding Aversive Stimuli in the Mesolimbic Dopamine System

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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