A nanoscale adhesion layer to promote cell attachment on PEEK

T. Joseph Dennes, Jeffrey Schwartz

Research output: Contribution to journalArticlepeer-review

62 Scopus citations


A novel adhesion layer is described that enables covalent attachment of cell adherent molecules to the surfaces of poly(ethylene terephthalate) (PET) and poly(aryl-ether-ether-ketone) PEEK. Vapor of zirconium or titanium tetra(tert-butoxides) can be deposited on the surface of PET or PEEK at room temperature at a pressure of ca. 10 -3 mm Hg. The thickness of this layer can be controlled by exposure time and monitored by quartz crystal microgravimetry on a surrogate substrate. Controlled thermolysis of the deposited alkoxide gives the metal a mixed oxide-alkoxide layer, which reacts with solutions of phosphonic acids to attach monolayer films of phosphonates, several of which are shown to significantly enhance cell growth compared with the untreated surface.

Original languageEnglish (US)
Pages (from-to)3456-3457
Number of pages2
JournalJournal of the American Chemical Society
Issue number10
StatePublished - Mar 18 2009

All Science Journal Classification (ASJC) codes

  • General Chemistry
  • Biochemistry
  • Catalysis
  • Colloid and Surface Chemistry


Dive into the research topics of 'A nanoscale adhesion layer to promote cell attachment on PEEK'. Together they form a unique fingerprint.

Cite this