A multifaceted signal recorder of cellular experiences using Cas12a base-editing

Pengfei Zhang; Michelle M. Chan

doi:10.1016/j.tibtech.2022.07.009

A multifaceted signal recorder of cellular experiences using Cas12a base-editing

Pengfei Zhang
, Michelle M. Chan

Molecular Biology

Research output: Contribution to journal › Short survey › peer-review

1 Scopus citations

Abstract

Technological advances have led to the emergence of lineage tracers, but signal recorders for mammalian systems have remained elusive. Kempton et al. have developed a Cas12a base-editing signal recorder capable of capturing diverse signals and operating in various experimental designs. The recorder enables new opportunities to chronicle cellular history.

Original language	English (US)
Pages (from-to)	1279-1281
Number of pages	3
Journal	Trends in Biotechnology
Volume	40
Issue number	11
DOIs	https://doi.org/10.1016/j.tibtech.2022.07.009
State	Published - Nov 2022

All Science Journal Classification (ASJC) codes

Bioengineering
Biotechnology

Keywords

CRISPR-Cas12a
DNA mutation
base editor
molecular recording
signaling

Access to Document

10.1016/j.tibtech.2022.07.009

Cite this

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title = "A multifaceted signal recorder of cellular experiences using Cas12a base-editing",

abstract = "Technological advances have led to the emergence of lineage tracers, but signal recorders for mammalian systems have remained elusive. Kempton et al. have developed a Cas12a base-editing signal recorder capable of capturing diverse signals and operating in various experimental designs. The recorder enables new opportunities to chronicle cellular history.",

keywords = "CRISPR-Cas12a, DNA mutation, base editor, molecular recording, signaling",

author = "Pengfei Zhang and Chan, \{Michelle M.\}",

note = "Publisher Copyright: {\textcopyright} 2022",

year = "2022",

month = nov,

doi = "10.1016/j.tibtech.2022.07.009",

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journal = "Trends in Biotechnology",

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T1 - A multifaceted signal recorder of cellular experiences using Cas12a base-editing

AU - Zhang, Pengfei

AU - Chan, Michelle M.

PY - 2022/11

Y1 - 2022/11

N2 - Technological advances have led to the emergence of lineage tracers, but signal recorders for mammalian systems have remained elusive. Kempton et al. have developed a Cas12a base-editing signal recorder capable of capturing diverse signals and operating in various experimental designs. The recorder enables new opportunities to chronicle cellular history.

AB - Technological advances have led to the emergence of lineage tracers, but signal recorders for mammalian systems have remained elusive. Kempton et al. have developed a Cas12a base-editing signal recorder capable of capturing diverse signals and operating in various experimental designs. The recorder enables new opportunities to chronicle cellular history.

KW - CRISPR-Cas12a

KW - DNA mutation

KW - base editor

KW - molecular recording

KW - signaling

UR - https://www.scopus.com/pages/publications/85135298745

UR - https://www.scopus.com/pages/publications/85135298745#tab=citedBy

U2 - 10.1016/j.tibtech.2022.07.009

DO - 10.1016/j.tibtech.2022.07.009

M3 - Short survey

C2 - 35933268

AN - SCOPUS:85135298745

SN - 0167-7799

VL - 40

SP - 1279

EP - 1281

JO - Trends in Biotechnology

JF - Trends in Biotechnology

IS - 11

ER -

A multifaceted signal recorder of cellular experiences using Cas12a base-editing

Abstract

All Science Journal Classification (ASJC) codes

Keywords

Access to Document

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