A multifaceted signal recorder of cellular experiences using Cas12a base-editing

Pengfei Zhang, Michelle M. Chan

Research output: Contribution to journalShort surveypeer-review

Abstract

Technological advances have led to the emergence of lineage tracers, but signal recorders for mammalian systems have remained elusive. Kempton et al. have developed a Cas12a base-editing signal recorder capable of capturing diverse signals and operating in various experimental designs. The recorder enables new opportunities to chronicle cellular history.

Original languageEnglish (US)
JournalTrends in Biotechnology
DOIs
StateAccepted/In press - 2022

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering

Keywords

  • CRISPR-Cas12a
  • DNA mutation
  • base editor
  • molecular recording
  • signaling

Fingerprint

Dive into the research topics of 'A multifaceted signal recorder of cellular experiences using Cas12a base-editing'. Together they form a unique fingerprint.

Cite this