A multifaceted signal recorder of cellular experiences using Cas12a base-editing

Pengfei Zhang; Michelle M. Chan

doi:10.1016/j.tibtech.2022.07.009

A multifaceted signal recorder of cellular experiences using Cas12a base-editing

Pengfei Zhang, Michelle M. Chan

Molecular Biology

Research output: Contribution to journal › Short survey › peer-review

Abstract

Technological advances have led to the emergence of lineage tracers, but signal recorders for mammalian systems have remained elusive. Kempton et al. have developed a Cas12a base-editing signal recorder capable of capturing diverse signals and operating in various experimental designs. The recorder enables new opportunities to chronicle cellular history.

Original language	English (US)
Pages (from-to)	1279-1281
Number of pages	3
Journal	Trends in Biotechnology
Volume	40
Issue number	11
DOIs	https://doi.org/10.1016/j.tibtech.2022.07.009
State	Published - Nov 2022

All Science Journal Classification (ASJC) codes

Bioengineering
Biotechnology

Keywords

CRISPR-Cas12a
DNA mutation
base editor
molecular recording
signaling

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10.1016/j.tibtech.2022.07.009

Cite this

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title = "A multifaceted signal recorder of cellular experiences using Cas12a base-editing",

abstract = "Technological advances have led to the emergence of lineage tracers, but signal recorders for mammalian systems have remained elusive. Kempton et al. have developed a Cas12a base-editing signal recorder capable of capturing diverse signals and operating in various experimental designs. The recorder enables new opportunities to chronicle cellular history.",

keywords = "CRISPR-Cas12a, DNA mutation, base editor, molecular recording, signaling",

author = "Pengfei Zhang and Chan, {Michelle M.}",

note = "Publisher Copyright: {\textcopyright} 2022",

year = "2022",

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doi = "10.1016/j.tibtech.2022.07.009",

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AU - Zhang, Pengfei

AU - Chan, Michelle M.

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N2 - Technological advances have led to the emergence of lineage tracers, but signal recorders for mammalian systems have remained elusive. Kempton et al. have developed a Cas12a base-editing signal recorder capable of capturing diverse signals and operating in various experimental designs. The recorder enables new opportunities to chronicle cellular history.

AB - Technological advances have led to the emergence of lineage tracers, but signal recorders for mammalian systems have remained elusive. Kempton et al. have developed a Cas12a base-editing signal recorder capable of capturing diverse signals and operating in various experimental designs. The recorder enables new opportunities to chronicle cellular history.

KW - CRISPR-Cas12a

KW - DNA mutation

KW - base editor

KW - molecular recording

KW - signaling

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ER -

A multifaceted signal recorder of cellular experiences using Cas12a base-editing

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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