A multifaceted gradient in human cerebellum of structural and functional development

Xingyu Liu; Federico d’Oleire Uquillas; Angela N. Viaene; Zonglei Zhen; Jesse Gomez

doi:10.1038/s41593-022-01136-z

A multifaceted gradient in human cerebellum of structural and functional development

Xingyu Liu, Federico d’Oleire Uquillas, Angela N. Viaene, Zonglei Zhen, Jesse Gomez

Princeton Neuroscience Institute

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

The organization of the basic tissue and functional properties of the cerebellum across development is unknown. Combining several large datasets, we demonstrate in the human cerebellum a static tissue gradient in adults that mirrors a similar growth-rate gradient across development. Quantitative tissue metrics corroborate unique densities of certain lipids and proteins among lobules, and cerebellar structural development closely follows cerebellar functional properties through childhood.

Original language	English (US)
Pages (from-to)	1129-1133
Number of pages	5
Journal	Nature neuroscience
Volume	25
Issue number	9
DOIs	https://doi.org/10.1038/s41593-022-01136-z
State	Published - Sep 2022

All Science Journal Classification (ASJC) codes

General Neuroscience

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title = "A multifaceted gradient in human cerebellum of structural and functional development",

abstract = "The organization of the basic tissue and functional properties of the cerebellum across development is unknown. Combining several large datasets, we demonstrate in the human cerebellum a static tissue gradient in adults that mirrors a similar growth-rate gradient across development. Quantitative tissue metrics corroborate unique densities of certain lipids and proteins among lobules, and cerebellar structural development closely follows cerebellar functional properties through childhood.",

author = "Xingyu Liu and {d{\textquoteright}Oleire Uquillas}, Federico and Viaene, {Angela N.} and Zonglei Zhen and Jesse Gomez",

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AU - Gomez, Jesse

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N2 - The organization of the basic tissue and functional properties of the cerebellum across development is unknown. Combining several large datasets, we demonstrate in the human cerebellum a static tissue gradient in adults that mirrors a similar growth-rate gradient across development. Quantitative tissue metrics corroborate unique densities of certain lipids and proteins among lobules, and cerebellar structural development closely follows cerebellar functional properties through childhood.

AB - The organization of the basic tissue and functional properties of the cerebellum across development is unknown. Combining several large datasets, we demonstrate in the human cerebellum a static tissue gradient in adults that mirrors a similar growth-rate gradient across development. Quantitative tissue metrics corroborate unique densities of certain lipids and proteins among lobules, and cerebellar structural development closely follows cerebellar functional properties through childhood.

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A multifaceted gradient in human cerebellum of structural and functional development

Abstract

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