A mouse model for HIV-1 entry

John Pietzsch, Henning Gruell, Stylianos Bournazos, Bridget M. Donovan, Florian Klein, Ron Diskin, Michael S. Seaman, Pamela J. Bjorkman, Jeffrey V. Ravetch, Alexander Ploss, Michel C. Nussenzweig

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Abstract

Passive transfer of neutralizing antibodies against HIV-1 can prevent infection in macaques and seems to delay HIV-1 rebound in humans. Anti-HIV antibodies are therefore of great interest for vaccine design. However, the basis for their in vivo activity has been difficult to evaluate systematically because of a paucity of small animal models for HIV infection. Here we report a genetically humanized mouse model that incorporates a luciferase reporter for rapid quantitation of HIV entry. An antibody's ability to block viral entry in this in vivo model is a function of its bioavailability, direct neutralizing activity, and effector functions.

Original languageEnglish (US)
Pages (from-to)15859-15864
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume109
Issue number39
DOIs
StatePublished - Sep 25 2012

All Science Journal Classification (ASJC) codes

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    Pietzsch, J., Gruell, H., Bournazos, S., Donovan, B. M., Klein, F., Diskin, R., Seaman, M. S., Bjorkman, P. J., Ravetch, J. V., Ploss, A., & Nussenzweig, M. C. (2012). A mouse model for HIV-1 entry. Proceedings of the National Academy of Sciences of the United States of America, 109(39), 15859-15864. https://doi.org/10.1073/pnas.1213409109