A modular monolayer coating enables cell targeting by luminescent yttria nanoparticles

Christopher A. Traina, T. Joseph Dennes, Jeffrey Schwartz

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Luminescent Eu+-doped Y2O3 nanoparticles are functionalized for cell targeting using a modular, multisegmented approach based on a phosphonate monolayer platform. The first segment provides hydrolytic stability for the particle-organic interface; the second enables aqueous suspendability; the third is used to bond cell attachment molecules. In vitro imaging experiments showed enhanced cell attachment of activated nanoparticles conjugated with cell attachment peptides compared to control nanoparticles. Peptide-derivatized nanoparticles are not displaced from the cells by their soluble peptide analogue, which suggests strong, polyvalent cell-particle interactions.

Original languageEnglish (US)
Pages (from-to)437-439
Number of pages3
JournalBioconjugate Chemistry
Issue number3
StatePublished - Mar 2009

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biotechnology
  • Biomedical Engineering
  • Pharmacology
  • Pharmaceutical Science
  • Organic Chemistry


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