A modular, air-stable nickel precatalyst

Jason D. Shields, Erin E. Gray, Abigail G. Doyle

Research output: Contribution to journalArticlepeer-review

110 Scopus citations


The synthesis and catalytic activity of [(TMEDA)Ni(o-tolyl)Cl], an air-stable, crystalline solid, is described. This complex is an effective precatalyst in a variety of nickel-catalyzed transformations. The lability of TMEDA allows a wide variety of ligands to be used, including mono- and bidentate phosphines, diimines, and N-heterocyclic carbenes. Preliminary mechanistic studies are also reported, which suggest that [(TMEDA)Ni(o-tolyl)Cl] can activate by either a Ni-B or Ni-Ni transmetalation event, depending on the reaction conditions.

Original languageEnglish (US)
Pages (from-to)2166-2169
Number of pages4
JournalOrganic letters
Issue number9
StatePublished - May 1 2015

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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