A microbial factory for defensive kahalalides in a tripartite marine symbiosis

Jindong Zan, Zhiyuan Li, Ma Diarey Tianero, Jeanette Davis, Russell T. Hill, Mohamed S. Abou Donia

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Chemical defense against predators is widespread in natural ecosystems. Occasionally, taxonomically distant organisms share the same defense chemical. Here, we describe an unusual tripartite marine symbiosis, in which an intracellular bacterial symbiont (“Candidatus Endobryopsis kahalalidefaciens”) uses a diverse array of biosynthetic enzymes to convert simple substrates into a library of complex molecules (the kahalalides) for chemical defense of the host, the alga Bryopsis sp., against predation. The kahalalides are subsequently hijacked by a third partner, the herbivorous mollusk Elysia rufescens, and employed similarly for defense. “Ca. E. kahalalidefaciens” has lost many essential traits for free living and acts as a factory for kahalalide production. This interaction between a bacterium, an alga, and an animal highlights the importance of chemical defense in the evolution of complex symbioses.

Original languageEnglish (US)
Article numbereaaw6732
JournalScience
Volume364
Issue number6445
DOIs
StatePublished - Jun 14 2019

All Science Journal Classification (ASJC) codes

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