A metabolic strategy to reverse fibrosis?

Joshua D. Rabinowitz, Gökhan M. Mutlu

Research output: Contribution to journalComment/debatepeer-review

18 Scopus citations


Fibrosis is characterized by excessive extracellular matrix (ECM) production relative to catabolism. A new study shows that the fuel choice of fibroblasts impacts this balance, with glycolysis promoting ECM synthesis and fatty acid oxidation stimulating ECM degradation.

Original languageEnglish (US)
Pages (from-to)12-13
Number of pages2
JournalNature Metabolism
Issue number1
StatePublished - Jan 1 2019

All Science Journal Classification (ASJC) codes

  • Physiology (medical)
  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Cell Biology


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