A metabolic strategy to reverse fibrosis?

Joshua D. Rabinowitz; Gökhan M. Mutlu

doi:10.1038/s42255-018-0013-8

A metabolic strategy to reverse fibrosis?

Joshua D. Rabinowitz, Gökhan M. Mutlu

Research output: Contribution to journal › Comment/debate › peer-review

21 Scopus citations

Abstract

Fibrosis is characterized by excessive extracellular matrix (ECM) production relative to catabolism. A new study shows that the fuel choice of fibroblasts impacts this balance, with glycolysis promoting ECM synthesis and fatty acid oxidation stimulating ECM degradation.

Original language	English (US)
Pages (from-to)	12-13
Number of pages	2
Journal	Nature Metabolism
Volume	1
Issue number	1
DOIs	https://doi.org/10.1038/s42255-018-0013-8
State	Published - Jan 1 2019

All Science Journal Classification (ASJC) codes

Physiology (medical)
Internal Medicine
Endocrinology, Diabetes and Metabolism
Cell Biology

Access to Document

10.1038/s42255-018-0013-8

Cite this

@article{05a816a2f5d54d779b62af43a12092a1,

title = "A metabolic strategy to reverse fibrosis?",

abstract = "Fibrosis is characterized by excessive extracellular matrix (ECM) production relative to catabolism. A new study shows that the fuel choice of fibroblasts impacts this balance, with glycolysis promoting ECM synthesis and fatty acid oxidation stimulating ECM degradation.",

author = "Rabinowitz, {Joshua D.} and Mutlu, {G{\"o}khan M.}",

note = "Publisher Copyright: {\textcopyright} 2019, Springer Nature Limited.",

year = "2019",

month = jan,

day = "1",

doi = "10.1038/s42255-018-0013-8",

language = "English (US)",

volume = "1",

pages = "12--13",

journal = "Nature Metabolism",

issn = "2522-5812",