A Map-like Micro-Organization of Grid Cells in the Medial Entorhinal Cortex

Yi Gu, Sam Lewallen, Amina A. Kinkhabwala, Cristina Domnisoru, Kijung Yoon, Jeffrey L. Gauthier, Ila R. Fiete, David W. Tank

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

How the topography of neural circuits relates to their function remains unclear. Although topographic maps exist for sensory and motor variables, they are rarely observed for cognitive variables. Using calcium imaging during virtual navigation, we investigated the relationship between the anatomical organization and functional properties of grid cells, which represent a cognitive code for location during navigation. We found a substantial degree of grid cell micro-organization in mouse medial entorhinal cortex: grid cells and modules all clustered anatomically. Within a module, the layout of grid cells was a noisy two-dimensional lattice in which the anatomical distribution of grid cells largely matched their spatial tuning phases. This micro-arrangement of phases demonstrates the existence of a topographical map encoding a cognitive variable in rodents. It contributes to a foundation for evaluating circuit models of the grid cell network and is consistent with continuous attractor models as the mechanism of grid formation. Grid cells, which represent a cognitive code for location during navigation, are arranged so that their anatomical organization largely matches their spatial tuning phases.

Original languageEnglish (US)
Pages (from-to)736-750.e30
JournalCell
Volume175
Issue number3
DOIs
StatePublished - Oct 18 2018

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Keywords

  • calcium imaging
  • continuous attractor network models
  • grid cell
  • grid module
  • grid phase
  • medial entorhinal cortex
  • microprism
  • pyramidal cell
  • stellate cell
  • virtual reality

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  • Cite this

    Gu, Y., Lewallen, S., Kinkhabwala, A. A., Domnisoru, C., Yoon, K., Gauthier, J. L., Fiete, I. R., & Tank, D. W. (2018). A Map-like Micro-Organization of Grid Cells in the Medial Entorhinal Cortex. Cell, 175(3), 736-750.e30. https://doi.org/10.1016/j.cell.2018.08.066