(Graph Presented) Design and light: A photocleavable synthetic moiety is ligated to the C terminus of a recombinant protein. In the ligated state, the chemical and protein components influence the properties of one another. Upon irradiation with light, both elements are released and their respective function is recovered. In this way a protein can be delivered into living cells and activated by UV irradiation at a desired time or location.
All Science Journal Classification (ASJC) codes
- Bioorganic chemistry
- Drug delivery