Rh(CO)2(acac)/TangPhos was found to be a highly enantioselective catalyst for asymmetric hydroformylation of norbornylene under mild conditions. Application of the protocol to the desymmetrization of other [2.2.1]-bicyclic olefins gave moderate to excellent enantioselectivity (55-92% ee).
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry
- [2.2.1]-Bicyclic olefin
- Asymmetric hydroformylation