Abstract
Rh(CO)2(acac)/TangPhos was found to be a highly enantioselective catalyst for asymmetric hydroformylation of norbornylene under mild conditions. Application of the protocol to the desymmetrization of other [2.2.1]-bicyclic olefins gave moderate to excellent enantioselectivity (55-92% ee).
Original language | English (US) |
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Pages (from-to) | 7831-7834 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 46 |
Issue number | 45 |
DOIs | |
State | Published - Nov 7 2005 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Biochemistry
- Drug Discovery
- Organic Chemistry
Keywords
- Asymmetric hydroformylation
- TangPhos
- [2.2.1]-Bicyclic olefin