A highly enantioselective asymmetric hydrogenation route to β-(2R,3S)-methyltryptophan

R. Scott Hoerrner; David Askin; R. P. Volante; Paul J. Reider

doi:10.1016/S0040-4039(98)00604-2

A highly enantioselective asymmetric hydrogenation route to β-(2R,3S)-methyltryptophan

R. Scott Hoerrner, David Askin, R. P. Volante, Paul J. Reider

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

Asymmetric hydrogenation of a protected (Z)-dehydro-β-methyltryptophan derivative 2 with (R,R)-Me-DuPHOS-Rh catalysis was achieved in 97 % ee. Deprotection then afforded (2R,3S)-β-methyltryptophan 1.

Original language	English (US)
Pages (from-to)	3455-3458
Number of pages	4
Journal	Tetrahedron Letters
Volume	39
Issue number	21
DOIs	https://doi.org/10.1016/S0040-4039(98)00604-2
State	Published - May 21 1998
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

Access to Document

10.1016/S0040-4039(98)00604-2

Cite this

@article{1af85ec9de104b069379cf2f1c50cdc7,

title = "A highly enantioselective asymmetric hydrogenation route to β-(2R,3S)-methyltryptophan",

abstract = "Asymmetric hydrogenation of a protected (Z)-dehydro-β-methyltryptophan derivative 2 with (R,R)-Me-DuPHOS-Rh catalysis was achieved in 97 % ee. Deprotection then afforded (2R,3S)-β-methyltryptophan 1.",

author = "Hoerrner, {R. Scott} and David Askin and Volante, {R. P.} and Reider, {Paul J.}",

year = "1998",

month = may,

day = "21",

doi = "10.1016/S0040-4039(98)00604-2",

language = "English (US)",

volume = "39",

pages = "3455--3458",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Ltd",

number = "21",

}

TY - JOUR

T1 - A highly enantioselective asymmetric hydrogenation route to β-(2R,3S)-methyltryptophan

AU - Hoerrner, R. Scott

AU - Askin, David

AU - Volante, R. P.

AU - Reider, Paul J.

PY - 1998/5/21

Y1 - 1998/5/21

N2 - Asymmetric hydrogenation of a protected (Z)-dehydro-β-methyltryptophan derivative 2 with (R,R)-Me-DuPHOS-Rh catalysis was achieved in 97 % ee. Deprotection then afforded (2R,3S)-β-methyltryptophan 1.

AB - Asymmetric hydrogenation of a protected (Z)-dehydro-β-methyltryptophan derivative 2 with (R,R)-Me-DuPHOS-Rh catalysis was achieved in 97 % ee. Deprotection then afforded (2R,3S)-β-methyltryptophan 1.

UR - http://www.scopus.com/inward/record.url?scp=0001762703&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0001762703&partnerID=8YFLogxK

U2 - 10.1016/S0040-4039(98)00604-2

DO - 10.1016/S0040-4039(98)00604-2

M3 - Article

AN - SCOPUS:0001762703

SN - 0040-4039

VL - 39

SP - 3455

EP - 3458

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 21

ER -

A highly enantioselective asymmetric hydrogenation route to β-(2R,3S)-methyltryptophan

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this