A highly enantioselective asymmetric hydrogenation route to β-(2R,3S)-methyltryptophan

R. Scott Hoerrner, David Askin, R. P. Volante, Paul J. Reider

Research output: Contribution to journalArticle

47 Scopus citations

Abstract

Asymmetric hydrogenation of a protected (Z)-dehydro-β-methyltryptophan derivative 2 with (R,R)-Me-DuPHOS-Rh catalysis was achieved in 97 % ee. Deprotection then afforded (2R,3S)-β-methyltryptophan 1.

Original languageEnglish (US)
Pages (from-to)3455-3458
Number of pages4
JournalTetrahedron Letters
Volume39
Issue number21
DOIs
StatePublished - May 21 1998
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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