Abstract
Synthesis of 2-[3-aminopropyl]-5,6,7,8-tetrahydronaphthyridine was accomplished via a one-pot double Suzuki reaction followed by deprotection and a highly regioselective intramolecular Chichibabin cyclization. A variety of reactions conditions were screened for the Chichibabin cyclization including choice of base, solvent and reaction temperature.
Original language | English (US) |
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Pages (from-to) | 6811-6814 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 42 |
Issue number | 39 |
DOIs | |
State | Published - Sep 24 2001 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Biochemistry
- Drug Discovery
- Organic Chemistry
Keywords
- Amination
- Cyclization
- Naphthyridines
- Suzuki-Miyaura reactions