TY - JOUR
T1 - A high-stringency blueprint of the human proteome
AU - Adhikari, Subash
AU - Nice, Edouard C.
AU - Deutsch, Eric W.
AU - Lane, Lydie
AU - Omenn, Gilbert S.
AU - Pennington, Stephen R.
AU - Paik, Young Ki
AU - Overall, Christopher M.
AU - Corrales, Fernando J.
AU - Cristea, Ileana M.
AU - Van Eyk, Jennifer E.
AU - Uhlén, Mathias
AU - Lindskog, Cecilia
AU - Chan, Daniel W.
AU - Bairoch, Amos
AU - Waddington, James C.
AU - Justice, Joshua L.
AU - LaBaer, Joshua
AU - Rodriguez, Henry
AU - He, Fuchu
AU - Kostrzewa, Markus
AU - Ping, Peipei
AU - Gundry, Rebekah L.
AU - Stewart, Peter
AU - Srivastava, Sanjeeva
AU - Srivastava, Sudhir
AU - Nogueira, Fabio C.S.
AU - Domont, Gilberto B.
AU - Vandenbrouck, Yves
AU - Lam, Maggie P.Y.
AU - Wennersten, Sara
AU - Vizcaino, Juan Antonio
AU - Wilkins, Marc
AU - Schwenk, Jochen M.
AU - Lundberg, Emma
AU - Bandeira, Nuno
AU - Marko-Varga, Gyorgy
AU - Weintraub, Susan T.
AU - Pineau, Charles
AU - Kusebauch, Ulrike
AU - Moritz, Robert L.
AU - Ahn, Seong Beom
AU - Palmblad, Magnus
AU - Snyder, Michael P.
AU - Aebersold, Ruedi
AU - Baker, Mark S.
N1 - Funding Information:
HUPO acknowledges collaborators, proteomic scientists, independent partners, industry vendors and members of the scientific community who have contributed to the HPP. A full alphabetical listing of the Human Proteome Project members appears in the Supplementary Information. In recognition of the many accomplishments, HUPO has produced a publicly available HPP timeline available through https://hupo.org/ Proteomics-Timeline to be released with this HPP Blueprint. Parts of this work were supported by grants to ProteoRed PRB3-ISCIII, PT17/0019/0001 Comunidad de Madrid Grant B2017/BMD-3817 (F.J.C.); Korean Ministry of Health and Welfare HI13C2098 and HI16C0257 (Y.K.P.); NIH grants P30ES017885 and U24CA210967 (G.S.O.), 5U01HL-13104204, PADOM-SPO11347 and PARYB-SPO112285 (M.P.S.); NCI CPTAC U24CA210985 and NCI EDRN U24CA115102 (D.W.C.); NIH National Institute of General Medical Sciences R01GM087221 (E.W.D./R.L.M.) and R24GM127667 (E.W.D.); NIH National Institute on Aging U19AG023122 (R.L.M.); NSF DBI-1933311 (E.W.D.); CIHR COVID-19 Rapid Research Funding (F20-01013), CIHR Foundation Grant FDN:14840 and Canada Research Chair (C.M.O.); Investissement d’Avenir Infrastructures Nationales en Biologie et Santé ANR-10-INBS-08 (Proteomics French Infrastructure ProFI (Y.V.); Wellcome Trust WT101477MA and 208391/Z/17/Z (J.A.V.); Knut and Alice Wallenberg Foundation (M.U., C.L., J.M.S., E.L.); Brazilian CAPES 88887.130697, CNPq 440613/2016-7, FAPERJ E-26/210.173/2018 (G.B.D.) and FAPERJ E-26/202.650/2018 (F.C.S.N.), Australian Commonwealth NCRIS (M.S.B.); NHMRC 1010303 (M.S.B., E.C.N.); Cancer Council NSW RG19-04 (M.S.B., S.B.A., E.C.N.); Cancer Institute NSW Fellowship 15/ECF/1-38 (S.B.A.), Sydney Vital CINSW Translational Cancer Research Centre grant (M.S.B., S.B.A., S.A.), ‘Fight on the Beaches’ (M.S.B., S.B.A., E.C.N., S.A.) funding and an International Macquarie Research Excellence Scholarship (S.A.). M.S.B. thanks the Faculty of Medicine, Stanford University for a sabbatical visiting professorship.
Publisher Copyright:
© 2020, The Author(s).
PY - 2020/12/1
Y1 - 2020/12/1
N2 - The Human Proteome Organization (HUPO) launched the Human Proteome Project (HPP) in 2010, creating an international framework for global collaboration, data sharing, quality assurance and enhancing accurate annotation of the genome-encoded proteome. During the subsequent decade, the HPP established collaborations, developed guidelines and metrics, and undertook reanalysis of previously deposited community data, continuously increasing the coverage of the human proteome. On the occasion of the HPP’s tenth anniversary, we here report a 90.4% complete high-stringency human proteome blueprint. This knowledge is essential for discerning molecular processes in health and disease, as we demonstrate by highlighting potential roles the human proteome plays in our understanding, diagnosis and treatment of cancers, cardiovascular and infectious diseases.
AB - The Human Proteome Organization (HUPO) launched the Human Proteome Project (HPP) in 2010, creating an international framework for global collaboration, data sharing, quality assurance and enhancing accurate annotation of the genome-encoded proteome. During the subsequent decade, the HPP established collaborations, developed guidelines and metrics, and undertook reanalysis of previously deposited community data, continuously increasing the coverage of the human proteome. On the occasion of the HPP’s tenth anniversary, we here report a 90.4% complete high-stringency human proteome blueprint. This knowledge is essential for discerning molecular processes in health and disease, as we demonstrate by highlighting potential roles the human proteome plays in our understanding, diagnosis and treatment of cancers, cardiovascular and infectious diseases.
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U2 - 10.1038/s41467-020-19045-9
DO - 10.1038/s41467-020-19045-9
M3 - Review article
C2 - 33067450
AN - SCOPUS:85092744472
SN - 2041-1723
VL - 11
JO - Nature communications
JF - Nature communications
IS - 1
M1 - 5301
ER -