TY - JOUR
T1 - A graphene-based electrochemical sensor for sensitive detection of paracetamol
AU - Kang, Xinhuang
AU - Wang, Jun
AU - Wu, Hong
AU - Liu, Jun
AU - Aksay, Ilhan A.
AU - Lin, Yuehe
N1 - Funding Information:
The work was supported by a laboratory-directed research and development program at Pacific Northwest National Laboratory (PNNL). The TEM and SEM works described in this paper were performed at the Environmental Molecular Sciences Laboratory, a national scientific user facility sponsored by DOE's Office of Biological and Environmental Research and located at PNNL. PNNL is operated for DOE by Battelle under Contract DE-AC05-76RL01830. X. Kang gratefully acknowledges the award of a PNNL fellowship to perform this work at PNNL. Ilhan A. Aksay acknowledges support from Army Research Office (ARO)/Multidisciplinary Research Initiative (MURI) under grant number W911NF-04-1-0170, W911F-09-1-0476, and the Directed Technologies, Inc.
PY - 2010/5/15
Y1 - 2010/5/15
N2 - An electrochemical sensor based on the electrocatalytic activity of functionalized graphene for sensitive detection of paracetamol is presented. The electrochemical behaviors of paracetamol on graphene-modified glassy carbon electrodes (GCEs) were investigated by cyclic voltammetry and square-wave voltammetry. The results showed that the graphene-modified electrode exhibited excellent electrocatalytic activity to paracetamol. A quasi-reversible redox process of paracetamol at the modified electrode was obtained, and the over-potential of paracetamol decreased significantly compared with that at the bare GCE. Such electrocatalytic behavior of graphene is attributed to its unique physical and chemical properties, e.g., subtle electronic characteristics, attractive π-π interaction, and strong adsorptive capability. This electrochemical sensor shows an excellent performance for detecting paracetamol with a detection limit of 3.2 × 10-8 M, a reproducibility of 5.2% relative standard deviation, and a satisfied recovery from 96.4% to 103.3%. The sensor shows great promise for simple, sensitive, and quantitative detection and screening of paracetamol.
AB - An electrochemical sensor based on the electrocatalytic activity of functionalized graphene for sensitive detection of paracetamol is presented. The electrochemical behaviors of paracetamol on graphene-modified glassy carbon electrodes (GCEs) were investigated by cyclic voltammetry and square-wave voltammetry. The results showed that the graphene-modified electrode exhibited excellent electrocatalytic activity to paracetamol. A quasi-reversible redox process of paracetamol at the modified electrode was obtained, and the over-potential of paracetamol decreased significantly compared with that at the bare GCE. Such electrocatalytic behavior of graphene is attributed to its unique physical and chemical properties, e.g., subtle electronic characteristics, attractive π-π interaction, and strong adsorptive capability. This electrochemical sensor shows an excellent performance for detecting paracetamol with a detection limit of 3.2 × 10-8 M, a reproducibility of 5.2% relative standard deviation, and a satisfied recovery from 96.4% to 103.3%. The sensor shows great promise for simple, sensitive, and quantitative detection and screening of paracetamol.
KW - Graphene
KW - Paracetamol
KW - Pharmaceutical preparation tablets
KW - Square-wave voltammetry
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U2 - 10.1016/j.talanta.2010.01.009
DO - 10.1016/j.talanta.2010.01.009
M3 - Article
C2 - 20298849
AN - SCOPUS:77949283983
SN - 0039-9140
VL - 81
SP - 754
EP - 759
JO - Talanta
JF - Talanta
IS - 3
ER -