A global assembly line for cyanobactins

Mohamed S. Donia; Jacques Ravel; Eric W. Schmidt

doi:10.1038/nchembio.84

A global assembly line for cyanobactins

Mohamed S. Donia
, Jacques Ravel
, Eric W. Schmidt

Research output: Contribution to journal › Article › peer-review

248 Scopus citations

Abstract

More than 100 cyclic peptides harboring heterocyclized residues are known from marine ascidians, sponges and different genera of cyanobacteria. Here, we report an assembly line responsible for the biosynthesis of these diverse peptides, now called cyanobactins, both in symbiotic and free-living cyanobacteria. By comparing five new cyanobactin biosynthetic clusters, we produced the prenylated antitumor preclinical candidate trunkamide in Escherichia coli culture using genetic engineering.

Original language	English (US)
Pages (from-to)	341-343
Number of pages	3
Journal	Nature Chemical Biology
Volume	4
Issue number	6
DOIs	https://doi.org/10.1038/nchembio.84
State	Published - Jun 2008
Externally published	Yes

All Science Journal Classification (ASJC) codes

Molecular Biology
Cell Biology

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10.1038/nchembio.84

Cite this

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title = "A global assembly line for cyanobactins",

abstract = "More than 100 cyclic peptides harboring heterocyclized residues are known from marine ascidians, sponges and different genera of cyanobacteria. Here, we report an assembly line responsible for the biosynthesis of these diverse peptides, now called cyanobactins, both in symbiotic and free-living cyanobacteria. By comparing five new cyanobactin biosynthetic clusters, we produced the prenylated antitumor preclinical candidate trunkamide in Escherichia coli culture using genetic engineering.",

author = "Donia, \{Mohamed S.\} and Jacques Ravel and Schmidt, \{Eric W.\}",

note = "Funding Information: This work was supported by grants from the US National Institutes of Health (GM071425) and the National Science Foundation (EF-0412226). We thank C. Ireland (University of Utah), the University of the South Pacific, the Solomon Islands and the Republic of the Fiji Islands for providing opportunities to collect marine animal samples. S. Meo (University of the South Pacific) aided with the collection of L. patella in Fiji. S. Carmeli (Tel-Aviv University) provided the N. spongiaeforme culture. J.G. Muller and T. Bugni (University of Utah) helped with mass spectrometry experiments. A. Bird and D. Winge (University of Utah) helped with yeast recombination. C. Ireland provided ascidian photos.",

year = "2008",

month = jun,

doi = "10.1038/nchembio.84",

language = "English (US)",

volume = "4",

pages = "341--343",

journal = "Nature Chemical Biology",

issn = "1552-4450",

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AU - Ravel, Jacques

AU - Schmidt, Eric W.

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PY - 2008/6

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N2 - More than 100 cyclic peptides harboring heterocyclized residues are known from marine ascidians, sponges and different genera of cyanobacteria. Here, we report an assembly line responsible for the biosynthesis of these diverse peptides, now called cyanobactins, both in symbiotic and free-living cyanobacteria. By comparing five new cyanobactin biosynthetic clusters, we produced the prenylated antitumor preclinical candidate trunkamide in Escherichia coli culture using genetic engineering.

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DO - 10.1038/nchembio.84

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JO - Nature Chemical Biology

JF - Nature Chemical Biology

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A global assembly line for cyanobactins

Abstract

All Science Journal Classification (ASJC) codes

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