@article{2eb47d5b2de741e09d3b7a85410910d1,
title = "A global assembly line for cyanobactins",
abstract = "More than 100 cyclic peptides harboring heterocyclized residues are known from marine ascidians, sponges and different genera of cyanobacteria. Here, we report an assembly line responsible for the biosynthesis of these diverse peptides, now called cyanobactins, both in symbiotic and free-living cyanobacteria. By comparing five new cyanobactin biosynthetic clusters, we produced the prenylated antitumor preclinical candidate trunkamide in Escherichia coli culture using genetic engineering.",
author = "Donia, {Mohamed S.} and Jacques Ravel and Schmidt, {Eric W.}",
note = "Funding Information: This work was supported by grants from the US National Institutes of Health (GM071425) and the National Science Foundation (EF-0412226). We thank C. Ireland (University of Utah), the University of the South Pacific, the Solomon Islands and the Republic of the Fiji Islands for providing opportunities to collect marine animal samples. S. Meo (University of the South Pacific) aided with the collection of L. patella in Fiji. S. Carmeli (Tel-Aviv University) provided the N. spongiaeforme culture. J.G. Muller and T. Bugni (University of Utah) helped with mass spectrometry experiments. A. Bird and D. Winge (University of Utah) helped with yeast recombination. C. Ireland provided ascidian photos.",
year = "2008",
month = jun,
doi = "10.1038/nchembio.84",
language = "English (US)",
volume = "4",
pages = "341--343",
journal = "Nature Chemical Biology",
issn = "1552-4450",
publisher = "Nature Publishing Group",
number = "6",
}