A global assembly line for cyanobactins

Mohamed S. Donia, Jacques Ravel, Eric W. Schmidt

Research output: Contribution to journalArticlepeer-review

191 Scopus citations

Abstract

More than 100 cyclic peptides harboring heterocyclized residues are known from marine ascidians, sponges and different genera of cyanobacteria. Here, we report an assembly line responsible for the biosynthesis of these diverse peptides, now called cyanobactins, both in symbiotic and free-living cyanobacteria. By comparing five new cyanobactin biosynthetic clusters, we produced the prenylated antitumor preclinical candidate trunkamide in Escherichia coli culture using genetic engineering.

Original languageEnglish (US)
Pages (from-to)341-343
Number of pages3
JournalNature Chemical Biology
Volume4
Issue number6
DOIs
StatePublished - Jun 2008

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

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