TY - JOUR
T1 - A genomewide survey of developmentally relevant genes in Ciona intestinalis. III. Genes for Fox, ETS, nuclear receptors and NFΚB
AU - Yagi, Kasumi
AU - Satou, Yutaka
AU - Mazet, Françoise
AU - Shimeld, Sebastian M.
AU - Degnan, Bernard
AU - Rokhsar, Daniel
AU - Levine, Michael
AU - Kohara, Yuji
AU - Satoh, Nori
N1 - Funding Information:
Acknowledgements This research was supported by Grants-in-Aid for Scientific Research from MEXT and JSPS, Japan to Y.S. (14704070) and N.S. (12202001). K.Y. was a Predoctoral Fellow of JSPS with a research grant (13003747). We thank Kazuko Hirayama, Chikako Imaizumi, Asako Fujimoto, and Hisayoshi Ishikawa for their technical support.
PY - 2003/6/1
Y1 - 2003/6/1
N2 - A survey against the draft genome sequence and the cDNA/EST database of Ciona intestinalis identified a number of genes encoding transcription factors regulating a variety of processes including development. In the present study, we describe almost complete sets of genes for Fox, ETS-domain transcription factors, nuclear receptors, and NFκB as well as other factors regulating NFκB activity, with their phylogenetic nature. Vertebrate Fox transcription factors are currently delineated into 17 subfamilies: FoxA to FoxQ. The present survey yielded 29 genes of this family in the Ciona genome, 24 of which were Ciona orthologues of known Fox genes. In addition, we found 15 ETS genes, 17 nuclear receptor genes, and several NFκB signaling pathway genes in the Ciona genome. The number of Ciona genes in each family is much smaller than that of vertebrates, which represents a simplified feature of the ascidian genome. For example, humans have two NFκB genes, three Rel genes, and five NFAT genes, while Ciona has one gene for each family. The Ciona genome also contains smaller numbers of genes for the NFκB regulatory system, i.e. after the split of ascidians/vertebrates, vertebrates evolved a more complex NFκB system. The present results therefore provide molecular information for the investigation of complex developmental processes, and an insight into chordate evolution.
AB - A survey against the draft genome sequence and the cDNA/EST database of Ciona intestinalis identified a number of genes encoding transcription factors regulating a variety of processes including development. In the present study, we describe almost complete sets of genes for Fox, ETS-domain transcription factors, nuclear receptors, and NFκB as well as other factors regulating NFκB activity, with their phylogenetic nature. Vertebrate Fox transcription factors are currently delineated into 17 subfamilies: FoxA to FoxQ. The present survey yielded 29 genes of this family in the Ciona genome, 24 of which were Ciona orthologues of known Fox genes. In addition, we found 15 ETS genes, 17 nuclear receptor genes, and several NFκB signaling pathway genes in the Ciona genome. The number of Ciona genes in each family is much smaller than that of vertebrates, which represents a simplified feature of the ascidian genome. For example, humans have two NFκB genes, three Rel genes, and five NFAT genes, while Ciona has one gene for each family. The Ciona genome also contains smaller numbers of genes for the NFκB regulatory system, i.e. after the split of ascidians/vertebrates, vertebrates evolved a more complex NFκB system. The present results therefore provide molecular information for the investigation of complex developmental processes, and an insight into chordate evolution.
KW - Ciona intestinalis
KW - ETS
KW - Fox
KW - NFΚB
KW - Nuclear receptors
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U2 - 10.1007/s00427-003-0322-z
DO - 10.1007/s00427-003-0322-z
M3 - Article
C2 - 12743820
AN - SCOPUS:0038786653
SN - 0949-944X
VL - 213
SP - 235
EP - 244
JO - Development Genes and Evolution
JF - Development Genes and Evolution
IS - 5-6
ER -