TY - JOUR
T1 - A genome-wide perspective on the evolutionary history of enigmatic wolf-like canids
AU - VonHoldt, Bridgett M.
AU - Pollinger, John P.
AU - Earl, Dent A.
AU - Knowles, James C.
AU - Boyko, Adam R.
AU - Parker, Heidi
AU - Geffen, Eli
AU - Pilot, Malgorzata
AU - Jedrzejewski, Wlodzimierz
AU - Jedrzejewska, Bogumila
AU - Sidorovich, Vadim
AU - Greco, Claudia
AU - Randi, Ettore
AU - Musiani, Marco
AU - Kays, Roland
AU - Bustamante, Carlos D.
AU - Ostrander, Elaine A.
AU - Novembre, John
AU - Wayne, Robert K.
PY - 2011/8
Y1 - 2011/8
N2 - High-throughput genotyping technologies developed for model species can potentially increase the resolution of demographic history and ancestry in wild relatives. We use a SNP genotyping microarray developed for the domestic dog to assay variation in over 48K loci in wolf-like species worldwide. Despite the high mobility of these large carnivores, we find distinct hierarchical population units within gray wolves and coyotes that correspond with geographic and ecologic differences among populations. Further, we test controversial theories about the ancestry of the Great Lakes wolf and red wolf using an analysis of haplotype blocks across all 38 canid autosomes. We find that these enigmatic canids are highly admixed varieties derived from gray wolves and coyotes, respectively. This divergent genomic history suggests that they do not have a shared recent ancestry as proposed by previous researchers. Interspecific hybridization, as well as the process of evolutionary divergence, may be responsible for the observed phenotypic distinction of both forms. Such admixture complicates decisions regarding endangered species restoration and protection.
AB - High-throughput genotyping technologies developed for model species can potentially increase the resolution of demographic history and ancestry in wild relatives. We use a SNP genotyping microarray developed for the domestic dog to assay variation in over 48K loci in wolf-like species worldwide. Despite the high mobility of these large carnivores, we find distinct hierarchical population units within gray wolves and coyotes that correspond with geographic and ecologic differences among populations. Further, we test controversial theories about the ancestry of the Great Lakes wolf and red wolf using an analysis of haplotype blocks across all 38 canid autosomes. We find that these enigmatic canids are highly admixed varieties derived from gray wolves and coyotes, respectively. This divergent genomic history suggests that they do not have a shared recent ancestry as proposed by previous researchers. Interspecific hybridization, as well as the process of evolutionary divergence, may be responsible for the observed phenotypic distinction of both forms. Such admixture complicates decisions regarding endangered species restoration and protection.
UR - http://www.scopus.com/inward/record.url?scp=80051553378&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80051553378&partnerID=8YFLogxK
U2 - 10.1101/gr.116301.110
DO - 10.1101/gr.116301.110
M3 - Article
C2 - 21566151
AN - SCOPUS:80051553378
SN - 1088-9051
VL - 21
SP - 1294
EP - 1305
JO - Genome Research
JF - Genome Research
IS - 8
ER -