A Genome-wide In Vitro Bacterial-Infection Screen Reveals Human Variation in the Host Response Associated with Inflammatory Disease

Keyphrases

• Animal Groups 20%
• Bacterial Infection 100%
• CARD8 100%
• Caspase-1 20%
• Cell Death 20%
• Cell-based 40%
• Common Genetic Variants 20%
• Disease Burden 20%
• Disease Susceptibility 20%
• Gain-of-function mutation 20%
• Genetic Differences 20%
• Genetic Variants 20%
• Genome Analysis 20%
• Genome-wide Studies 20%
• Genotype 20%
• Herding 20%
• Host Response 100%
• Human Genome 20%
• Human Health 20%
• Human Population 40%
• Human Variation 100%
• Induced Cell Death 20%
• Inflammatory Diseases 100%
• Large Mammals 20%
• Loss Function 20%
• Mechanistic Understanding 20%
• Microbes 20%
• Natural Selection 20%
• Orthologs 20%
• Overexpression 20%
• Population Expansion 20%
• Protease 20%
• RNA Interference 20%
• Salmonella 20%
• Systemic Inflammatory Response Syndrome 20%
• Variant Function 20%

Immunology and Microbiology

• Allele 100%
• Caspase 1 33%
• Cell Death 66%
• Genetic Difference 33%
• Genetic Variation 33%
• Herd 33%
• Human Genome 33%
• Immune Response 100%
• In Vitro 100%
• Infection 100%
• Infectious Disease 100%
• Inflammatory Disorder 100%
• Natural Selection 33%
• Orthology 33%
• Protease 33%
• Proteinase 33%
• RNAI 33%
• Salmonella 33%
• Single Isomorphous Replacement 33%
• Susceptibility 33%

Biochemistry, Genetics and Molecular Biology

• Allele 100%
• Caspase 1 33%
• Cell Death 66%
• Disease Burden 33%
• Genetic Difference 33%
• Genetic Divergence 66%
• Genetic Variation 33%
• Genotyping 33%
• Herd 33%
• Human Genome 33%
• Immune Response 100%
• Natural Selection 33%
• Orthology 33%
• Protease 33%
• RNAI 33%
• Salmonella 33%