A genetic analysis of the att-int-xis region of coliphage lambda

L. W. Enquist, R. A. Weisberg

Research output: Contribution to journalArticlepeer-review

60 Scopus citations

Abstract

We have isolated and characterized several hundred mutants of bacteriophage λ that are defective in prophage excision. Almost all resemble classical int and xis mutants in complementation pattern and ability to integrate. One int mutant is exceptional in that it is defective in excision but proficient in integration. The mutant sites are located in a region that begins within 50 base-pairs to the right of the attachment site and extends about 1350 base-pairs rightward, int is approximately 1240 base-pairs and xis 110 base-pairs long.

Original languageEnglish (US)
Pages (from-to)97-120
Number of pages24
JournalJournal of Molecular Biology
Volume111
Issue number2
DOIs
StatePublished - Apr 5 1977
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Structural Biology
  • Molecular Biology

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