A genetic analysis of the att-int-xis region of coliphage lambda

L. W. Enquist; R. A. Weisberg

doi:10.1016/S0022-2836(77)80117-4

A genetic analysis of the att-int-xis region of coliphage lambda

L. W. Enquist, R. A. Weisberg

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Abstract

We have isolated and characterized several hundred mutants of bacteriophage λ that are defective in prophage excision. Almost all resemble classical int and xis mutants in complementation pattern and ability to integrate. One int mutant is exceptional in that it is defective in excision but proficient in integration. The mutant sites are located in a region that begins within 50 base-pairs to the right of the attachment site and extends about 1350 base-pairs rightward, int is approximately 1240 base-pairs and xis 110 base-pairs long.

Original language	English (US)
Pages (from-to)	97-120
Number of pages	24
Journal	Journal of Molecular Biology
Volume	111
Issue number	2
DOIs	https://doi.org/10.1016/S0022-2836(77)80117-4
State	Published - Apr 5 1977

All Science Journal Classification (ASJC) codes

Molecular Biology
Structural Biology

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10.1016/S0022-2836(77)80117-4

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abstract = "We have isolated and characterized several hundred mutants of bacteriophage λ that are defective in prophage excision. Almost all resemble classical int and xis mutants in complementation pattern and ability to integrate. One int mutant is exceptional in that it is defective in excision but proficient in integration. The mutant sites are located in a region that begins within 50 base-pairs to the right of the attachment site and extends about 1350 base-pairs rightward, int is approximately 1240 base-pairs and xis 110 base-pairs long.",

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N2 - We have isolated and characterized several hundred mutants of bacteriophage λ that are defective in prophage excision. Almost all resemble classical int and xis mutants in complementation pattern and ability to integrate. One int mutant is exceptional in that it is defective in excision but proficient in integration. The mutant sites are located in a region that begins within 50 base-pairs to the right of the attachment site and extends about 1350 base-pairs rightward, int is approximately 1240 base-pairs and xis 110 base-pairs long.

AB - We have isolated and characterized several hundred mutants of bacteriophage λ that are defective in prophage excision. Almost all resemble classical int and xis mutants in complementation pattern and ability to integrate. One int mutant is exceptional in that it is defective in excision but proficient in integration. The mutant sites are located in a region that begins within 50 base-pairs to the right of the attachment site and extends about 1350 base-pairs rightward, int is approximately 1240 base-pairs and xis 110 base-pairs long.

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A genetic analysis of the att-int-xis region of coliphage lambda

Abstract

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