A General Small-Scale Reactor to Enable Standardization and Acceleration of Photocatalytic Reactions

Chi Chip Le; Michael K. Wismer; Zhi Cai Shi; Rui Zhang; Donald V. Conway; Guoqing Li; Petr Vachal; Ian W. Davies; David W.C. MacMillan

doi:10.1021/acscentsci.7b00159

A General Small-Scale Reactor to Enable Standardization and Acceleration of Photocatalytic Reactions

Chi Chip Le, Michael K. Wismer, Zhi Cai Shi, Rui Zhang, Donald V. Conway, Guoqing Li, Petr Vachal, Ian W. Davies, David W.C. MacMillan

Chemistry

Research output: Contribution to journal › Article › peer-review

79 Scopus citations

Abstract

Photocatalysis for organic synthesis has experienced an exponential growth in the past 10 years. However, the variety of experimental procedures that have been reported to perform photon-based catalyst excitation has hampered the establishment of general protocols to convert visible light into chemical energy. To address this issue, we have designed an integrated photoreactor for enhanced photon capture and catalyst excitation. Moreover, the evaluation of this new reactor in eight photocatalytic transformations that are widely employed in medicinal chemistry settings has confirmed significant performance advantages of this optimized design while enabling a standardized protocol.

Original language	English (US)
Pages (from-to)	647-653
Number of pages	7
Journal	ACS Central Science
Volume	3
Issue number	6
DOIs	https://doi.org/10.1021/acscentsci.7b00159
State	Published - Jun 28 2017

All Science Journal Classification (ASJC) codes

Chemistry(all)
Chemical Engineering(all)

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10.1021/acscentsci.7b00159

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title = "A General Small-Scale Reactor to Enable Standardization and Acceleration of Photocatalytic Reactions",

abstract = "Photocatalysis for organic synthesis has experienced an exponential growth in the past 10 years. However, the variety of experimental procedures that have been reported to perform photon-based catalyst excitation has hampered the establishment of general protocols to convert visible light into chemical energy. To address this issue, we have designed an integrated photoreactor for enhanced photon capture and catalyst excitation. Moreover, the evaluation of this new reactor in eight photocatalytic transformations that are widely employed in medicinal chemistry settings has confirmed significant performance advantages of this optimized design while enabling a standardized protocol.",

author = "Le, {Chi Chip} and Wismer, {Michael K.} and Shi, {Zhi Cai} and Rui Zhang and Conway, {Donald V.} and Guoqing Li and Petr Vachal and Davies, {Ian W.} and MacMillan, {David W.C.}",

note = "Funding Information: Financial support was provided by the NIH NIGMS (R01 GM103558-06) and kind gifts from Merck, Bristol-Myers Squibb, Abbvie, Janssen and Eli Lilly. We would like to thank the following scientists and engineers at Merck & Co., Inc., and Princeton University for input on reactor design and experimental and technical assistance during preproduction validation of the units. From Princeton University: Patricia Zhang, Megan Shaw, Ryan Evans, Russell Smith, Jack Twilton and Jack Terrett. From Merck & Co., Inc.",

year = "2017",

month = jun,

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doi = "10.1021/acscentsci.7b00159",

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journal = "ACS Central Science",

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A General Small-Scale Reactor to Enable Standardization and Acceleration of Photocatalytic Reactions. / Le, Chi Chip; Wismer, Michael K.; Shi, Zhi Cai; Zhang, Rui; Conway, Donald V.; Li, Guoqing; Vachal, Petr; Davies, Ian W.; MacMillan, David W.C.

In: ACS Central Science, Vol. 3, No. 6, 28.06.2017, p. 647-653.

Research output: Contribution to journal › Article › peer-review

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AU - Li, Guoqing

AU - Vachal, Petr

AU - Davies, Ian W.

AU - MacMillan, David W.C.

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