A general method for the highly diastereoselective, kinetically controlled alkylation of ( )-nopinone

Kevin R. Campos; Sandra Lee; Michel Journet; Jason J. Kowal; Dongwei Cai; Robert D. Larsen; Paul J. Reider

doi:10.1016/S0040-4039(02)01589-7

A general method for the highly diastereoselective, kinetically controlled alkylation of ( )-nopinone

Kevin R. Campos, Sandra Lee, Michel Journet, Jason J. Kowal, Dongwei Cai, Robert D. Larsen, Paul J. Reider

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

A general method for the monoalkylation of (+)-nopinone was developed for a variety of carbon and heteroatom electrophiles to afford the kinetically controlled product 2 with high diastereoselectivity (98% d.e.) and excellent yield (75-90%).

Original language	English (US)
Pages (from-to)	6957-6959
Number of pages	3
Journal	Tetrahedron Letters
Volume	43
Issue number	39
DOIs	https://doi.org/10.1016/S0040-4039(02)01589-7
State	Published - Sep 23 2002
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(02)01589-7

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title = "A general method for the highly diastereoselective, kinetically controlled alkylation of ( )-nopinone",

abstract = "A general method for the monoalkylation of (+)-nopinone was developed for a variety of carbon and heteroatom electrophiles to afford the kinetically controlled product 2 with high diastereoselectivity (98\% d.e.) and excellent yield (75-90\%).",

author = "Campos, \{Kevin R.\} and Sandra Lee and Michel Journet and Kowal, \{Jason J.\} and Dongwei Cai and Larsen, \{Robert D.\} and Reider, \{Paul J.\}",

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AU - Campos, Kevin R.

AU - Lee, Sandra

AU - Journet, Michel

AU - Kowal, Jason J.

AU - Cai, Dongwei

AU - Larsen, Robert D.

AU - Reider, Paul J.

PY - 2002/9/23

Y1 - 2002/9/23

N2 - A general method for the monoalkylation of (+)-nopinone was developed for a variety of carbon and heteroatom electrophiles to afford the kinetically controlled product 2 with high diastereoselectivity (98% d.e.) and excellent yield (75-90%).

AB - A general method for the monoalkylation of (+)-nopinone was developed for a variety of carbon and heteroatom electrophiles to afford the kinetically controlled product 2 with high diastereoselectivity (98% d.e.) and excellent yield (75-90%).

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U2 - 10.1016/S0040-4039(02)01589-7

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SN - 0040-4039

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 39

ER -

A general method for the highly diastereoselective, kinetically controlled alkylation of ( )-nopinone

Abstract

All Science Journal Classification (ASJC) codes

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