A general method for the monoalkylation of (+)-nopinone was developed for a variety of carbon and heteroatom electrophiles to afford the kinetically controlled product 2 with high diastereoselectivity (98% d.e.) and excellent yield (75-90%).
|Original language||English (US)|
|Number of pages||3|
|State||Published - Sep 23 2002|
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry