A general method for the highly diastereoselective, kinetically controlled alkylation of ( )-nopinone

Kevin R. Campos; Sandra Lee; Michel Journet; Jason J. Kowal; Dongwei Cai; Robert D. Larsen; Paul J. Reider

doi:10.1016/S0040-4039(02)01589-7

A general method for the highly diastereoselective, kinetically controlled alkylation of ( )-nopinone

Kevin R. Campos, Sandra Lee, Michel Journet, Jason J. Kowal, Dongwei Cai, Robert D. Larsen, Paul J. Reider

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

A general method for the monoalkylation of (+)-nopinone was developed for a variety of carbon and heteroatom electrophiles to afford the kinetically controlled product 2 with high diastereoselectivity (98% d.e.) and excellent yield (75-90%).

Original language	English (US)
Pages (from-to)	6957-6959
Number of pages	3
Journal	Tetrahedron Letters
Volume	43
Issue number	39
DOIs	https://doi.org/10.1016/S0040-4039(02)01589-7
State	Published - Sep 23 2002
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

Access to Document

10.1016/S0040-4039(02)01589-7

Cite this

@article{39b0eeca95194373a9f8c77af3822f28,

title = "A general method for the highly diastereoselective, kinetically controlled alkylation of ( )-nopinone",

abstract = "A general method for the monoalkylation of (+)-nopinone was developed for a variety of carbon and heteroatom electrophiles to afford the kinetically controlled product 2 with high diastereoselectivity (98% d.e.) and excellent yield (75-90%).",

author = "Campos, {Kevin R.} and Sandra Lee and Michel Journet and Kowal, {Jason J.} and Dongwei Cai and Larsen, {Robert D.} and Reider, {Paul J.}",

year = "2002",

month = sep,

day = "23",

doi = "10.1016/S0040-4039(02)01589-7",

language = "English (US)",

volume = "43",

pages = "6957--6959",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Limited",

number = "39",

}

TY - JOUR

T1 - A general method for the highly diastereoselective, kinetically controlled alkylation of ( )-nopinone

AU - Campos, Kevin R.

AU - Lee, Sandra

AU - Journet, Michel

AU - Kowal, Jason J.

AU - Cai, Dongwei

AU - Larsen, Robert D.

AU - Reider, Paul J.

PY - 2002/9/23

Y1 - 2002/9/23

N2 - A general method for the monoalkylation of (+)-nopinone was developed for a variety of carbon and heteroatom electrophiles to afford the kinetically controlled product 2 with high diastereoselectivity (98% d.e.) and excellent yield (75-90%).

AB - A general method for the monoalkylation of (+)-nopinone was developed for a variety of carbon and heteroatom electrophiles to afford the kinetically controlled product 2 with high diastereoselectivity (98% d.e.) and excellent yield (75-90%).

UR - http://www.scopus.com/inward/record.url?scp=0037163327&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037163327&partnerID=8YFLogxK

U2 - 10.1016/S0040-4039(02)01589-7

DO - 10.1016/S0040-4039(02)01589-7

M3 - Article

AN - SCOPUS:0037163327

SN - 0040-4039

VL - 43

SP - 6957

EP - 6959

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 39

ER -

A general method for the highly diastereoselective, kinetically controlled alkylation of ( )-nopinone

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this