A general method for the highly diastereoselective, kinetically controlled alkylation of ( )-nopinone

Kevin R. Campos, Sandra Lee, Michel Journet, Jason J. Kowal, Dongwei Cai, Robert D. Larsen, Paul J. Reider

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

A general method for the monoalkylation of (+)-nopinone was developed for a variety of carbon and heteroatom electrophiles to afford the kinetically controlled product 2 with high diastereoselectivity (98% d.e.) and excellent yield (75-90%).

Original languageEnglish (US)
Pages (from-to)6957-6959
Number of pages3
JournalTetrahedron Letters
Volume43
Issue number39
DOIs
StatePublished - Sep 23 2002
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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