A general method for the enantioselective synthesis of pantolactone derivatives

David A. Evans, Jimmy Wu, Craig E. Masse, David W.C. MacMillan

Research output: Contribution to journalArticle

49 Scopus citations

Abstract

(matrix presented) An efficient enantioselective synthesis of β,β-dialkyl-γ-substituted pantolactones has been achieved utilizing the cationic [Sc((S,S)-R-pybox)]-(Cl)2+, R = Ph (9), t-Bu (10), complex in a catalyzed aldol reaction as the key step. The pantolactone derivatives are isolated in enantiomeric excesses.

Original languageEnglish (US)
Pages (from-to)3379-3382
Number of pages4
JournalOrganic Letters
Volume4
Issue number20
DOIs
StatePublished - Oct 3 2002
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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